| Rank | Player | Home Runs | Years | ||
| 1. | Barry Bonds | 762 | 1986-2007 | ||
| 2. | Hank Aaron* | 755 | 1954-1976 | ||
| 3. | Babe Ruth* | 714 | 1914-1935 | ||
| 4. | Willie Mays* | 660 | 1951-1973 | ||
| 5. | Sammy Sosa | 609 | 1989-2007 | ||
| 6. | Ken Griffey | 593 | 1989-2007 | ||
| 7. | Frank Robinson* | 586 | 1956-1976 | ||
| 8. | Mark McGwire | 583 | 1986-2001 | ||
| 9. | Harmon Killebrew* | 573 | 1954-1975 | ||
| 10. | Rafael Palmeiro | 569 | 1986-2005 | ||
| 11. | Reggie Jackson* | 563 | 1967-1987 | ||
| 12. | Mike Schmidt* | 548 | 1972-1989 | ||
| 13. | Mickey Mantle* | 536 | 1951-1968 | ||
| 14. | Jimmie Foxx* | 534 | 1925-1945 | ||
| 15. | Ted Williams* | 521 | 1939-1960 | ||
| Willie McCovey* | 521 | 1959-1980 | |||
| 16. | Alex Rodriguez | 518 | 1994-2007 | ||
| 17. | Frank Thomas | 513 | 1990-2007 | ||
| 18. | Eddie Mathews* | 512 | 1952-1968 | ||
| Ernie Banks* | 512 | 1953-1971 | |||
| 19. | Mel Ott* | 511 | 1926-1947 | ||
| 20. | Jim Thome | 507 | 1991-2007 | ||
| 21. | Eddie Murray* | 504 | 1977-1997 | ||
| 22. | Lou Gehrig* | 493 | 1923-1939 | ||
| Fred McGriff | 493 | 1986-2004 | |||
| 23. | Manny Ramirez | 490 | 1993-2007 | ||
| 24. | Gary Sheffield | 480 | 1988-2007 | ||
| 25. | Stan Musial* | 475 | 1941-1963 | ||
| Willie Stargell* | 475 | 1962-1982 | |||
| 26. | Dave Winfield* | 465 | 1973-1995 | ||
| 27. | Jose Canseco | 462 | 1985-2001 | ||
| 28. | Carl Yastrzemski* | 452 | 1961-1983 | ||
| 29. | Jeff Bagwell | 449 | 1991-2005 | ||
| 30. | Dave Kingman | 442 | 1971-1986 | ||
| 31. | Andre Dawson | 438 | 1976-1996 | ||
| 32. | Juan Gonzalez | 434 | 1989-2005 | ||
| 33. | Cal Ripken* | 431 | 1981-2001 | ||
| Carlos Delgado | 431 | 1993-2007 | |||
| 34. | Mike Piazza | 427 | 1992-2007 | ||
| 35. | Billy Williams* | 426 | 1959-1976 | ||
| 36. | Darrell Evans | 414 | 1969-1989 | ||
| 37. | Duke Snider* | 407 | 1947-1964 | ||
| 38. | Andres Galarraga | 399 | 1985-2004 | ||
| Al Kaline* | 399 | 1953-1974 | |||
| 39. | Dale Murphy | 398 | 1976-1993 | ||
| 40. | Joe Carter | 396 | 1983-1998 | ||
| 41. | Graig Nettles | 390 | 1967-1988 | ||
| 42. | Johnny Bench* | 389 | 1967-1983 | ||
| 43. | Chipper Jones | 386 | 1993-2007 | ||
| 44. | Dwight Evans | 385 | 1972-1991 | ||
| 45. | Harold Baines | 384 | 1980-2001 | ||
| 46. | Larry Walker | 383 | 1989-2005 | ||
| 47. | Frank Howard | 382 | 1958-1973 | ||
| Jim Rice | 382 | 1974-1989 | |||
| 48. | Albert Belle | 381 | 1989-2000 | ||
| 49. | Tony Perez* | 379 | 1964-1986 | ||
| Orlando Cepeda* | 379 | 1958-1974 | |||
| 50. | Matt Williams | 378 | 1987-2003 | ||
| 51. | Norm Cash | 377 | 1958-1974 | ||
| 52. | Carlton Fisk* | 376 | 1969-1993 | ||
| 53. | Rocky Colavito | 374 | 1955-1968 | ||
| 54. | Gil Hodges | 370 | 1943-1963 | ||
| 55. | Ralph Kiner* | 369 | 1946-1955 | ||
| 56. | Andruw Jones | 368 | 1996-2007 | ||
| 57. | Vladimir Guerrero | 365 | 1996-2007 | ||
| Jeff Kent | 365 | 1992-2007 | |||
| 58. | Jason Giambi | 364 | 1995-2007 | ||
| 59. | Jim Edmonds | 362 | 1993-2007 | ||
| 60. | Joe DiMaggio* | 361 | 1936-1951 | ||
| 61. | Gary Gaetti | 360 | 1981-2000 | ||
| 62. | Johnny Mize* | 359 | 1936-1953 | ||
| 63. | Yogi Berra* | 358 | 1946-1965 | ||
| 64. | Greg Vaughn | 355 | 1989-2003 | ||
| 65. | Lee May | 354 | 1965-1982 | ||
| 66. | Ellis Burks | 352 | 1987-2004 | ||
| 67. | Dick Allen | 351 | 1963-1977 | ||
| 68. | Chili Davis | 350 | 1981-1999 | ||
| 69. | George Foster | 348 | 1969-1986 | ||
| 70. | Luis Gonzalez | 346 | 1990-2007 | ||
| 71. | Ron Santo | 342 | 1960-1974 | ||
| 72. | Jack Clark | 340 | 1975-1992 | ||
| 73. | Tino Martinez | 339 | 1990-2005 | ||
| Boog Powell | 339 | 1961-1977 | |||
| Dave Parker | 339 | 1973-1991 | |||
| 74. | Don Baylor | 338 | 1970-1988 | ||
| 75. | Joe Adcock | 336 | 1950-1966 | ||
| 76. | Darryl Strawberry | 335 | 1983-1999 | ||
| 77. | Moises Alou | 332 | 1990-2007 | ||
| Bobby Bonds | 332 | 1968-1981 | |||
| 78. | Hank Greenberg* | 331 | 1930-1947 | ||
| 79. | Mo Vaughn | 328 | 1991-2003 | ||
| Shawn Green | 328 | 1993-2007 | |||
| 80. | Willie Horton | 325 | 1963-1980 | ||
| 81. | Lance Parrish | 324 | 1977-1995 | ||
| Gary Carter* | 324 | 1974-1992 | |||
| 82. | Ron Gant | 321 | 1987-2003 | ||
| 83. | Vinny Castilla | 320 | 1991-2006 | ||
| 84. | Cecil Fielder | 319 | 1985-1998 | ||
| 85. | Roy Sievers | 318 | 1949-1965 | ||
| 86. | George Brett* | 317 | 1973-1993 |