| Rank | Player | OBP | Years | ||
| 1. | Ted Williams* | .482 | 1939-1960 | ||
| 2. | Babe Ruth* | .474 | 1914-1935 | ||
| 3. | John McGraw* | .466 | 1891-1906 | ||
| 4. | Billy Hamilton* | .455 | 1888-1901 | ||
| 5. | Lou Gehrig* | .447 | 1923-1939 | ||
| 6. | Barry Bonds | .444 | 1986-2007 | ||
| 7. | Bill Joyce | .435 | 1890-1898 | ||
| 8. | Rogers Hornsby* | .434 | 1915-1937 | ||
| 9. | Ty Cobb* | .433 | 1905-1928 | ||
| 10. | Todd Helton | .428 | 1997-2008 | ||
| 11. | Jimmie Foxx* | .428 | 1925-1945 | ||
| 12. | Tris Speaker* | .428 | 1907-1928 | ||
| 13. | Albert Pujols | .426 | 2001-2008 | ||
| 14. | Eddie Collins* | .424 | 1906-1930 | ||
| 15. | Ferris Fain | .424 | 1947-1955 | ||
| 16. | Dan Brouthers* | .423 | 1879-1904 | ||
| 17. | Joe Jackson | .423 | 1908-1920 | ||
| 18. | Max Bishop | .423 | 1924-1935 | ||
| 19. | Mickey Mantle* | .421 | 1951-1968 | ||
| 20. | Mickey Cochrane* | .419 | 1925-1937 | ||
| 21. | Frank Thomas | .419 | 1990-2008 | ||
| 22. | Edgar Martinez | .418 | 1987-2004 | ||
| 23. | Stan Musial* | .417 | 1941-1963 | ||
| 24. | Cupid Childs | .416 | 1888-1901 | ||
| 25. | Jesse Burkett* | .415 | 1890-1905 | ||
| 26. | Wade Boggs* | .415 | 1982-1999 | ||
| 27. | Mel Ott* | .414 | 1926-1947 | ||
| 28. | Roy Thomas | .413 | 1899-1911 | ||
| 29. | Lance Berkman | .413 | 1999-2008 | ||
| 30. | Lefty O'Doul | .413 | 1919-1934 | ||
| 31. | Hank Greenberg* | .412 | 1930-1947 | ||
| 32. | Ed Delahanty* | .411 | 1888-1903 | ||
| 33. | Manny Ramirez | .411 | 1993-2008 | ||
| 34. | Charlie Keller | .410 | 1939-1952 | ||
| 35. | Eddie Stanky | .410 | 1943-1953 | ||
| 36. | Harry Heilmann* | .410 | 1914-1932 | ||
| 37. | Jackie Robinson* | .409 | 1947-1956 | ||
| 38. | Jason Giambi | .409 | 1995-2008 | ||
| 39. | Jake Stenzel | .408 | 1890-1899 | ||
| 40. | Roy Cullenbine | .408 | 1938-1947 | ||
| 41. | Chipper Jones | .408 | 1993-2008 | ||
| 42. | Jeff Bagwell | .408 | 1991-2005 | ||
| 43. | Denny Lyons | .407 | 1885-1897 | ||
| 44. | Riggs Stephenson | .407 | 1921-1934 | ||
| 45. | Jim Thome | .406 | 1991-2008 | ||
| 46. | Arky Vaughan* | .406 | 1932-1948 | ||
| 47. | Bobby Abreu | .405 | 1996-2008 | ||
| 48. | Joe Harris | .404 | 1914-1928 | ||
| 49. | Paul Waner* | .404 | 1926-1945 | ||
| 50. | Brian Giles | .404 | 1995-2008 | ||
| 51. | Charlie Gehringer* | .404 | 1924-1942 | ||
| 52. | Joe Cunningham | .403 | 1954-1966 | ||
| 53. | Pete Browning | .403 | 1882-1894 | ||
| 54. | Lu Blue | .402 | 1921-1933 | ||
| 55. | Joe Kelley* | .402 | 1891-1908 | ||
| 56. | Rickey Henderson | .401 | 1979-2003 | ||
| 57. | Bill Lange | .401 | 1893-1899 | ||
| 58. | Larry Walker | .400 | 1989-2005 | ||
| 59. | George Selkirk | .400 | 1934-1942 | ||
| 60. | Luke Appling* | .399 | 1930-1950 | ||
| 61. | Ross Youngs* | .399 | 1917-1926 | ||
| 62. | Joe DiMaggio* | .398 | 1936-1951 | ||
| 63. | Elmer Valo | .398 | 1940-1961 | ||
| 64. | John Olerud | .398 | 1989-2005 | ||
| 65. | Ralph Kiner* | .398 | 1946-1955 | ||
| 66. | Elmer Smith | .398 | 1886-1901 | ||
| 67. | Ed Morgan | .398 | 1928-1934 | ||
| 68. | Johnny Mize* | .397 | 1936-1953 | ||
| 69. | Roger Connor* | .397 | 1880-1897 | ||
| 70. | Earle Combs* | .397 | 1924-1935 | ||
| 71. | John Kruk | .397 | 1986-1995 | ||
| 72. | Richie Ashburn* | .396 | 1948-1962 | ||
| 73. | Mike Hargrove | .396 | 1974-1985 | ||
| 74. | Hack Wilson* | .395 | 1923-1934 | ||
| 75. | Earl Averill* | .395 | 1929-1941 | ||
| 76. | Johnny Pesky | .394 | 1942-1954 | ||
| 77. | Mark McGwire | .394 | 1986-2001 | ||
| 78. | Stan Hack | .394 | 1932-1947 | ||
| 79. | Eddie Yost | .394 | 1944-1962 | ||
| 80. | Frank Chance* | .394 | 1898-1914 | ||
| 81. | Gary Sheffield | .394 | 1988-2008 | ||
| 82. | Ken Williams | .393 | 1915-1929 | ||
| 83. | Wally Schang | .393 | 1913-1931 | ||
| 84. | Rod Carew* | .393 | 1967-1985 | ||
| 85. | Bob Johnson | .393 | 1933-1945 | ||
| 86. | Bill Terry* | .393 | 1923-1936 | ||
| 87. | Cap Anson* | .393 | 1871-1897 | ||
| 88. | George Grantham | .392 | 1922-1934 | ||
| 89. | J.D. Drew | .392 | 1998-2008 | ||
| 90. | Tip O'Neill | .392 | 1883-1892 | ||
| 91. | Joe Morgan* | .392 | 1963-1984 | ||
| 92. | Jack Fournier | .392 | 1912-1927 | ||
| 93. | Mike Tiernan | .392 | 1887-1899 | ||
| 94. | Travis Hafner | .391 | 2002-2008 | ||
| 95. | Honus Wagner* | .391 | 1897-1917 | ||
| 96. | Joe Sewell* | .391 | 1920-1933 | ||
| 97. | Augie Galan | .390 | 1934-1949 | ||
| 98. | Hughie Jennings* | .390 | 1891-1918 | ||
| 99. | Dave Magadan | .390 | 1986-2001 | ||
| 100. | Harlond Clift | .390 | 1934-1945 |