| Rank | Player | Runs | Years | ||
| 1. | Rickey Henderson | 2295 | 1979-2003 | ||
| 2. | Ty Cobb* | 2246 | 1905-1928 | ||
| 3. | Barry Bonds | 2227 | 1986-2007 | ||
| 4. | Babe Ruth* | 2174 | 1914-1935 | ||
| Hank Aaron* | 2174 | 1954-1976 | |||
| 5. | Pete Rose | 2165 | 1963-1986 | ||
| 6. | Willie Mays* | 2062 | 1951-1973 | ||
| 7. | Cap Anson* | 1996 | 1871-1897 | ||
| 8. | Stan Musial* | 1949 | 1941-1963 | ||
| 9. | Lou Gehrig* | 1888 | 1923-1939 | ||
| 10. | Tris Speaker* | 1882 | 1907-1928 | ||
| 11. | Mel Ott* | 1859 | 1926-1947 | ||
| 12. | Craig Biggio | 1844 | 1988-2007 | ||
| 13. | Frank Robinson* | 1829 | 1956-1976 | ||
| 14. | Eddie Collins* | 1821 | 1906-1930 | ||
| 15. | Carl Yastrzemski* | 1816 | 1961-1983 | ||
| 16. | Ted Williams* | 1798 | 1939-1960 | ||
| 17. | Paul Molitor* | 1782 | 1978-1998 | ||
| 18. | Charlie Gehringer* | 1774 | 1924-1942 | ||
| 19. | Jimmie Foxx* | 1751 | 1925-1945 | ||
| 20. | Honus Wagner* | 1736 | 1897-1917 | ||
| 21. | Jim O'Rourke* | 1729 | 1872-1904 | ||
| 22. | Jesse Burkett* | 1720 | 1890-1905 | ||
| 23. | Willie Keeler* | 1719 | 1892-1910 | ||
| 24. | Billy Hamilton* | 1690 | 1888-1901 | ||
| 25. | Bid McPhee* | 1678 | 1882-1899 | ||
| 26. | Mickey Mantle* | 1677 | 1951-1968 | ||
| 27. | Dave Winfield* | 1669 | 1973-1995 | ||
| 28. | Rafael Palmeiro | 1663 | 1986-2005 | ||
| 29. | Joe Morgan* | 1650 | 1963-1984 | ||
| 30. | Cal Ripken* | 1647 | 1981-2001 | ||
| 31. | Jimmy Ryan | 1642 | 1885-1903 | ||
| 32. | George Van Haltren | 1639 | 1887-1903 | ||
| 33. | Robin Yount* | 1632 | 1974-1993 | ||
| 34. | Paul Waner* | 1627 | 1926-1945 | ||
| Eddie Murray* | 1627 | 1977-1997 | |||
| 35. | Al Kaline* | 1622 | 1953-1974 | ||
| 36. | Roger Connor* | 1620 | 1880-1897 | ||
| 37. | Fred Clarke* | 1619 | 1894-1915 | ||
| 38. | Ken Griffey | 1612 | 1989-2008 | ||
| 39. | Lou Brock* | 1610 | 1961-1979 | ||
| 40. | Alex Rodriguez | 1605 | 1994-2008 | ||
| 41. | Jake Beckley* | 1600 | 1888-1907 | ||
| 42. | Ed Delahanty* | 1599 | 1888-1903 | ||
| 43. | Gary Sheffield | 1592 | 1988-2008 | ||
| 44. | Bill Dahlen | 1589 | 1891-1911 | ||
| 45. | George Brett* | 1583 | 1973-1993 | ||
| 46. | Rogers Hornsby* | 1579 | 1915-1937 | ||
| 47. | Tim Raines | 1571 | 1979-2002 | ||
| 48. | Hugh Duffy* | 1552 | 1888-1906 | ||
| 49. | Reggie Jackson* | 1551 | 1967-1987 | ||
| 50. | Max Carey* | 1545 | 1910-1929 | ||
| 51. | George Davis* | 1539 | 1890-1909 | ||
| 52. | Frankie Frisch* | 1532 | 1919-1937 | ||
| 53. | Kenny Lofton | 1528 | 1991-2007 | ||
| 54. | Dan Brouthers* | 1523 | 1879-1904 | ||
| 55. | Tom Brown | 1521 | 1882-1898 | ||
| 56. | Jeff Bagwell | 1517 | 1991-2005 | ||
| 57. | Sam Rice* | 1514 | 1915-1934 | ||
| 58. | Wade Boggs* | 1513 | 1982-1999 | ||
| 59. | Eddie Mathews* | 1509 | 1952-1968 | ||
| 60. | Roberto Alomar | 1508 | 1988-2004 | ||
| 61. | Al Simmons* | 1507 | 1924-1944 | ||
| 62. | Mike Schmidt* | 1506 | 1972-1989 | ||
| 63. | Nap Lajoie* | 1504 | 1896-1916 | ||
| 64. | Frank Thomas | 1494 | 1990-2008 | ||
| 65. | Harry Stovey | 1492 | 1880-1893 | ||
| 66. | Goose Goslin* | 1483 | 1921-1938 | ||
| 67. | Arlie Latham | 1478 | 1880-1909 | ||
| 68. | Sammy Sosa | 1475 | 1989-2007 | ||
| 69. | Dwight Evans | 1470 | 1972-1991 | ||
| 70. | Derek Jeter | 1467 | 1995-2008 | ||
| 71. | Herman Long | 1455 | 1889-1904 | ||
| 72. | Manny Ramirez | 1444 | 1993-2008 | ||
| 73. | Steve Finley | 1443 | 1989-2007 | ||
| 74. | Jim Thome | 1431 | 1991-2008 | ||
| 75. | Harry Hooper* | 1429 | 1909-1925 | ||
| 76. | Dummy Hoy | 1426 | 1888-1902 | ||
| 77. | Rod Carew* | 1424 | 1967-1985 | ||
| 78. | Joe Kelley* | 1421 | 1891-1908 | ||
| 79. | Roberto Clemente* | 1416 | 1955-1972 | ||
| 80. | Luis Gonzalez | 1412 | 1990-2008 | ||
| 81. | Billy Williams* | 1410 | 1959-1976 | ||
| 82. | John Ward* | 1408 | 1878-1894 | ||
| 83. | Mike Griffin | 1405 | 1887-1898 | ||
| 84. | Sam Crawford* | 1391 | 1899-1917 | ||
| 85. | Joe DiMaggio* | 1390 | 1936-1951 | ||
| 86. | Lou Whitaker | 1386 | 1977-1995 | ||
| 87. | Tony Gwynn* | 1383 | 1982-2001 | ||
| 88. | Chipper Jones | 1378 | 1993-2008 | ||
| 89. | Johnny Damon | 1376 | 1995-2008 | ||
| 90. | Andre Dawson | 1373 | 1976-1996 | ||
| 91. | Bernie Williams | 1366 | 1991-2006 | ||
| Vada Pinson | 1366 | 1958-1975 | |||
| 92. | Omar Vizquel | 1361 | 1989-2008 | ||
| 93. | Brett Butler | 1359 | 1981-1997 | ||
| 94. | King Kelly* | 1357 | 1878-1893 | ||
| Doc Cramer | 1357 | 1929-1948 | |||
| 95. | Larry Walker | 1355 | 1989-2005 | ||
| Tommy Leach | 1355 | 1898-1918 |