| Rank | Player | Strikeouts | Years | ||
| 1. | Reggie Jackson* | 2597 | 1967-1987 | ||
| 2. | Sammy Sosa | 2306 | 1989-2007 | ||
| 3. | Jim Thome | 2190 | 1991-2008 | ||
| 4. | Andres Galarraga | 2003 | 1985-2004 | ||
| 5. | Jose Canseco | 1942 | 1985-2001 | ||
| 6. | Willie Stargell* | 1936 | 1962-1982 | ||
| 7. | Mike Schmidt* | 1883 | 1972-1989 | ||
| 8. | Fred McGriff | 1882 | 1986-2004 | ||
| 9. | Tony Perez* | 1867 | 1964-1986 | ||
| 10. | Dave Kingman | 1816 | 1971-1986 | ||
| 11. | Bobby Bonds | 1757 | 1968-1981 | ||
| 12. | Craig Biggio | 1753 | 1988-2007 | ||
| 13. | Dale Murphy | 1748 | 1976-1993 | ||
| 14. | Lou Brock* | 1730 | 1961-1979 | ||
| 15. | Carlos Delgado | 1725 | 1993-2008 | ||
| 16. | Mickey Mantle* | 1710 | 1951-1968 | ||
| 17. | Harmon Killebrew* | 1699 | 1954-1975 | ||
| 18. | Chili Davis | 1698 | 1981-1999 | ||
| 19. | Dwight Evans | 1697 | 1972-1991 | ||
| 20. | Rickey Henderson | 1694 | 1979-2003 | ||
| 21. | Dave Winfield* | 1686 | 1973-1995 | ||
| 22. | Ken Griffey | 1682 | 1989-2008 | ||
| 23. | Jim Edmonds | 1669 | 1993-2008 | ||
| 24. | Manny Ramirez | 1667 | 1993-2008 | ||
| 25. | Mike Cameron | 1642 | 1995-2008 | ||
| 26. | Alex Rodriguez | 1641 | 1994-2008 | ||
| 27. | Reggie Sanders | 1614 | 1991-2007 | ||
| 28. | Gary Gaetti | 1602 | 1981-2000 | ||
| 29. | Mark McGwire | 1596 | 1986-2001 | ||
| 30. | Lee May | 1570 | 1965-1982 | ||
| 31. | Jeff Bagwell | 1558 | 1991-2005 | ||
| 32. | Dick Allen | 1556 | 1963-1977 | ||
| 33. | Ray Lankford | 1550 | 1990-2004 | ||
| Willie McCovey* | 1550 | 1959-1980 | |||
| 34. | Barry Bonds | 1539 | 1986-2007 | ||
| 35. | Dave Parker | 1537 | 1973-1991 | ||
| 36. | Frank Robinson* | 1532 | 1956-1976 | ||
| 37. | Lance Parrish | 1527 | 1977-1995 | ||
| 38. | Devon White | 1526 | 1985-2001 | ||
| Willie Mays* | 1526 | 1951-1973 | |||
| 39. | Jeff Kent | 1522 | 1992-2008 | ||
| 40. | Eddie Murray* | 1516 | 1977-1997 | ||
| 41. | Greg Vaughn | 1513 | 1989-2003 | ||
| Rick Monday | 1513 | 1966-1984 | |||
| 42. | Andre Dawson | 1509 | 1976-1996 | ||
| 43. | Tony Phillips | 1499 | 1982-1999 | ||
| 44. | Greg Luzinski | 1495 | 1970-1984 | ||
| 45. | Eddie Mathews* | 1487 | 1952-1968 | ||
| 46. | Andruw Jones | 1470 | 1996-2008 | ||
| 47. | Frank Howard | 1460 | 1958-1973 | ||
| 48. | Jay Bell | 1443 | 1986-2003 | ||
| 49. | Juan Samuel | 1442 | 1983-1998 | ||
| 50. | Harold Baines | 1441 | 1980-2001 | ||
| Jack Clark | 1441 | 1975-1992 | |||
| 51. | Mo Vaughn | 1429 | 1991-2003 | ||
| 52. | Jimmy Wynn | 1427 | 1963-1977 | ||
| 53. | Jim Rice | 1423 | 1974-1989 | ||
| 54. | George Foster | 1419 | 1969-1986 | ||
| 55. | George Scott | 1418 | 1966-1979 | ||
| 56. | Royce Clayton | 1415 | 1991-2007 | ||
| 57. | Ron Gant | 1411 | 1987-2003 | ||
| 58. | Darrell Evans | 1410 | 1969-1989 | ||
| 59. | Rob Deer | 1409 | 1984-1996 | ||
| 60. | Jay Buhner | 1406 | 1987-2001 | ||
| 61. | Bobby Abreu | 1405 | 1996-2008 | ||
| 62. | Eric Davis | 1398 | 1984-2001 | ||
| 63. | Frank Thomas | 1397 | 1990-2008 | ||
| 64. | Carl Yastrzemski* | 1393 | 1961-1983 | ||
| 65. | Jose Hernandez | 1391 | 1991-2006 | ||
| 66. | Joe Carter | 1387 | 1983-1998 | ||
| 67. | Carlton Fisk* | 1386 | 1969-1993 | ||
| 68. | Hank Aaron* | 1383 | 1954-1976 | ||
| 69. | Derek Jeter | 1376 | 1995-2008 | ||
| Jeromy Burnitz | 1376 | 1993-2006 | |||
| 70. | Travis Fryman | 1369 | 1990-2002 | ||
| 71. | Matt Williams | 1363 | 1987-2003 | ||
| 72. | Danny Tartabull | 1362 | 1984-1997 | ||
| 73. | Tim Salmon | 1360 | 1992-2006 | ||
| 74. | Larry Parrish | 1359 | 1974-1988 | ||
| 75. | Darryl Strawberry | 1352 | 1983-1999 | ||
| 76. | Robin Yount* | 1350 | 1974-1993 | ||
| 77. | Rafael Palmeiro | 1348 | 1986-2005 | ||
| 78. | Ron Santo | 1343 | 1960-1974 | ||
| 79. | Julio Franco | 1341 | 1982-2007 | ||
| 80. | Ellis Burks | 1340 | 1987-2004 | ||
| 81. | Gorman Thomas | 1339 | 1973-1986 | ||
| 82. | Dean Palmer | 1332 | 1989-2003 | ||
| 83. | Babe Ruth* | 1330 | 1914-1935 | ||
| 84. | Deron Johnson | 1318 | 1960-1976 | ||
| 85. | Cecil Fielder | 1316 | 1985-1998 | ||
| 86. | Shawn Green | 1315 | 1993-2007 | ||
| 87. | Willie Horton | 1313 | 1963-1980 | ||
| Richie Sexson | 1313 | 1997-2008 | |||
| 88. | Jimmie Foxx* | 1311 | 1925-1945 | ||
| 89. | Jason Giambi | 1308 | 1995-2008 | ||
| 90. | Tim Wallach | 1307 | 1980-1996 | ||
| Mickey Tettleton | 1307 | 1984-1997 | |||
| 91. | Cal Ripken* | 1305 | 1981-2001 | ||
| 92. | Steve Finley | 1299 | 1989-2007 | ||
| 93. | Bret Boone | 1295 | 1992-2005 |