| Rank | Player | Runs | Year | Age | ||
| 1. | Billy Hamilton* | 192 | 1894 | 28 | ||
| 2. | Babe Ruth* | 177 | 1921 | 26 | ||
| Tom Brown | 177 | 1891 | 30 | |||
| 3. | Lou Gehrig* | 167 | 1936 | 32 | ||
| Tip O'Neill | 167 | 1887 | 29 | |||
| 4. | Billy Hamilton* | 166 | 1895 | 29 | ||
| 5. | Willie Keeler* | 165 | 1894 | 22 | ||
| Joe Kelley* | 165 | 1894 | 22 | |||
| 6. | Lou Gehrig* | 163 | 1931 | 27 | ||
| Babe Ruth* | 163 | 1928 | 33 | |||
| Arlie Latham | 163 | 1887 | 27 | |||
| 7. | Willie Keeler* | 162 | 1895 | 23 | ||
| 8. | Hugh Duffy* | 161 | 1890 | 23 | ||
| 9. | Jesse Burkett* | 160 | 1896 | 27 | ||
| Hugh Duffy* | 160 | 1894 | 27 | |||
| Fred Dunlap | 160 | 1884 | 25 | |||
| 10. | Hughie Jennings* | 159 | 1895 | 26 | ||
| 11. | Chuck Klein* | 158 | 1930 | 25 | ||
| Babe Ruth* | 158 | 1927 | 32 | |||
| Babe Ruth* | 158 | 1920 | 25 | |||
| Bobby Lowe | 158 | 1894 | 28 | |||
| 12. | Rogers Hornsby* | 156 | 1929 | 33 | ||
| John McGraw* | 156 | 1894 | 21 | |||
| 13. | Kiki Cuyler* | 155 | 1930 | 31 | ||
| King Kelly* | 155 | 1886 | 28 | |||
| 14. | Willie Keeler* | 153 | 1896 | 24 | ||
| Jesse Burkett* | 153 | 1895 | 26 | |||
| Dan Brouthers* | 153 | 1887 | 29 | |||
| 15. | Jeff Bagwell | 152 | 2000 | 32 | ||
| Chuck Klein* | 152 | 1932 | 27 | |||
| Al Simmons* | 152 | 1930 | 28 | |||
| Woody English | 152 | 1930 | 24 | |||
| Lefty O'Doul | 152 | 1929 | 32 | |||
| Billy Hamilton* | 152 | 1897 | 31 | |||
| Billy Hamilton* | 152 | 1896 | 30 | |||
| Harry Stovey | 152 | 1889 | 32 | |||
| Mike Griffin | 152 | 1889 | 24 | |||
| Arlie Latham | 152 | 1886 | 26 | |||
| 16. | Joe DiMaggio* | 151 | 1937 | 22 | ||
| Jimmie Foxx* | 151 | 1932 | 24 | |||
| Babe Ruth* | 151 | 1923 | 28 | |||
| 17. | Ted Williams* | 150 | 1949 | 30 | ||
| Babe Ruth* | 150 | 1930 | 35 | |||
| George Gore | 150 | 1886 | 29 | |||
| 18. | Babe Ruth* | 149 | 1931 | 36 | ||
| Lou Gehrig* | 149 | 1927 | 23 | |||
| Ed Delahanty* | 149 | 1895 | 27 | |||
| Bill Dahlen | 149 | 1894 | 24 | |||
| Herman Long | 149 | 1893 | 27 | |||
| 19. | Joe Kelley* | 148 | 1896 | 24 | ||
| Joe Kelley* | 148 | 1895 | 23 | |||
| Jake Stenzel | 148 | 1894 | 26 | |||
| Hub Collins | 148 | 1890 | 26 | |||
| 20. | Ty Cobb* | 147 | 1911 | 24 | ||
| Ed Delahanty* | 147 | 1894 | 26 | |||
| Hugh Duffy* | 147 | 1893 | 26 | |||
| Mike Tiernan | 147 | 1889 | 22 | |||
| 21. | Sammy Sosa | 146 | 2001 | 32 | ||
| Craig Biggio | 146 | 1997 | 31 | |||
| Rickey Henderson | 146 | 1985 | 26 | |||
| Hack Wilson* | 146 | 1930 | 30 | |||
| Tom Brown | 146 | 1890 | 29 | |||
| Darby O'Brien | 146 | 1889 | 25 | |||
| 22. | Harlond Clift | 145 | 1936 | 23 | ||
| Nap Lajoie* | 145 | 1901 | 26 | |||
| Willie Keeler* | 145 | 1897 | 25 | |||
| Patsy Donovan | 145 | 1894 | 29 | |||
| Ed Delahanty* | 145 | 1893 | 25 | |||
| Jesse Burkett* | 145 | 1893 | 24 | |||
| Cupid Childs | 145 | 1893 | 25 | |||
| 23. | Hank Greenberg* | 144 | 1938 | 27 | ||
| Charlie Gehringer* | 144 | 1936 | 33 | |||
| Al Simmons* | 144 | 1932 | 30 | |||
| Charlie Gehringer* | 144 | 1930 | 27 | |||
| Kiki Cuyler* | 144 | 1925 | 26 | |||
| Ty Cobb* | 144 | 1915 | 28 | |||
| Billy Hamilton* | 144 | 1889 | 23 | |||
| Hugh Duffy* | 144 | 1889 | 22 | |||
| 24. | Alex Rodriguez | 143 | 2007 | 31 | ||
| Jeff Bagwell | 143 | 1999 | 31 | |||
| Larry Walker | 143 | 1997 | 30 | |||
| Lenny Dykstra | 143 | 1993 | 30 | |||
| Red Rolfe | 143 | 1937 | 28 | |||
| Earle Combs* | 143 | 1932 | 33 | |||
| Babe Herman | 143 | 1930 | 26 | |||
| Lou Gehrig* | 143 | 1930 | 26 | |||
| Babe Ruth* | 143 | 1924 | 29 | |||
| John McGraw* | 143 | 1898 | 25 | |||
| Cupid Childs | 143 | 1894 | 26 | |||
| 25. | Ellis Burks | 142 | 1996 | 31 | ||
| Ted Williams* | 142 | 1946 | 27 | |||
| Paul Waner* | 142 | 1928 | 25 | |||
| Jesse Burkett* | 142 | 1901 | 32 | |||
| Harry Stovey | 142 | 1890 | 33 | |||
| Mike Griffin | 142 | 1887 | 22 | |||
| 26. | Alex Rodriguez | 141 | 1996 | 20 | ||
| Ted Williams* | 141 | 1942 | 23 | |||
| Rogers Hornsby* | 141 | 1922 | 26 | |||
| Billy Hamilton* | 141 | 1891 | 25 | |||
| 27. | Chuck Knoblauch | 140 | 1996 | 27 |