| Rank | Player | Strikeouts | Year | Age | ||
| 1. | Mark Reynolds | 204 | 2008 | 24 | ||
| 2. | Ryan Howard | 199 | 2008 | 28 | ||
| Ryan Howard | 199 | 2007 | 27 | |||
| 3. | Jack Cust | 197 | 2008 | 29 | ||
| 4. | Adam Dunn | 195 | 2004 | 24 | ||
| 5. | Adam Dunn | 194 | 2006 | 26 | ||
| 6. | Bobby Bonds | 189 | 1970 | 24 | ||
| 7. | Jose Hernandez | 188 | 2002 | 32 | ||
| 8. | Preston Wilson | 187 | 2000 | 25 | ||
| Bobby Bonds | 187 | 1969 | 23 | |||
| 9. | Rob Deer | 186 | 1987 | 26 | ||
| 10. | Jose Hernandez | 185 | 2001 | 31 | ||
| Jim Thome | 185 | 2001 | 30 | |||
| Pete Incaviglia | 185 | 1986 | 22 | |||
| 11. | Jim Thome | 182 | 2003 | 32 | ||
| Cecil Fielder | 182 | 1990 | 26 | |||
| 12. | Ryan Howard | 181 | 2006 | 26 | ||
| Mo Vaughn | 181 | 2000 | 32 | |||
| 13. | Mike Schmidt* | 180 | 1975 | 25 | ||
| 14. | Rob Deer | 179 | 1986 | 25 | ||
| 15. | Richie Sexson | 178 | 2001 | 26 | ||
| 16. | Mark Bellhorn | 177 | 2004 | 29 | ||
| Jose Hernandez | 177 | 2003 | 33 | |||
| 17. | Mike Cameron | 176 | 2002 | 29 | ||
| 18. | Jay Buhner | 175 | 1997 | 32 | ||
| Rob Deer | 175 | 1991 | 30 | |||
| Jose Canseco | 175 | 1986 | 21 | |||
| Gorman Thomas | 175 | 1979 | 28 | |||
| Dave Nicholson | 175 | 1963 | 23 | |||
| 19. | Curtis Granderson | 174 | 2006 | 25 | ||
| Sammy Sosa | 174 | 1997 | 28 | |||
| 20. | Bo Jackson | 172 | 1989 | 26 | ||
| Jim Presley | 172 | 1986 | 24 | |||
| 21. | Dan Uggla | 171 | 2008 | 28 | ||
| Jim Thome | 171 | 2000 | 29 | |||
| Jim Thome | 171 | 1999 | 28 | |||
| Sammy Sosa | 171 | 1999 | 30 | |||
| Sammy Sosa | 171 | 1998 | 29 | |||
| Reggie Jackson* | 171 | 1968 | 22 | |||
| 22. | Adam Dunn | 170 | 2002 | 22 | ||
| Gorman Thomas | 170 | 1980 | 29 | |||
| 23. | Craig Wilson | 169 | 2004 | 27 | ||
| Rob Deer | 169 | 1993 | 32 | |||
| Andres Galarraga | 169 | 1990 | 28 | |||
| 24. | Adam Dunn | 168 | 2005 | 25 | ||
| Corey Patterson | 168 | 2004 | 24 | |||
| Sammy Sosa | 168 | 2000 | 31 | |||
| Pete Incaviglia | 168 | 1987 | 23 | |||
| Juan Samuel | 168 | 1984 | 23 | |||
| 25. | Dan Uggla | 167 | 2007 | 27 | ||
| Richie Sexson | 167 | 2005 | 30 | |||
| Jim Edmonds | 167 | 2000 | 29 | |||
| 26. | Carlos Pena | 166 | 2008 | 30 | ||
| Cory Snyder | 166 | 1987 | 24 | |||
| Steve Balboni | 166 | 1985 | 28 | |||
| Gary Alexander | 166 | 1978 | 25 | |||
| 27. | Chris Young | 165 | 2008 | 24 | ||
| Adam Dunn | 165 | 2007 | 27 | |||
| 28. | Adam Dunn | 164 | 2008 | 28 | ||
| Jack Cust | 164 | 2007 | 28 | |||
| Derrek Lee | 164 | 2002 | 26 | |||
| 29. | Troy Glaus | 163 | 2000 | 23 | ||
| Donn Clendenon | 163 | 1968 | 32 | |||
| 30. | Bill Hall | 162 | 2006 | 26 | ||
| Pat Burrell | 162 | 2001 | 24 | |||
| Ron Gant | 162 | 1997 | 32 | |||
| Juan Samuel | 162 | 1987 | 26 | |||
| Butch Hobson | 162 | 1977 | 25 | |||
| 31. | Brad Wilkerson | 161 | 2002 | 24 | ||
| Reggie Jackson* | 161 | 1971 | 25 | |||
| Dick Allen | 161 | 1968 | 26 | |||
| 32. | Mike Cameron | 160 | 2007 | 34 | ||
| Alfonso Soriano | 160 | 2006 | 30 | |||
| Pat Burrell | 160 | 2005 | 28 | |||
| Henry Rodriguez | 160 | 1996 | 28 | |||
| Mickey Tettleton | 160 | 1990 | 29 | |||
| 33. | Ben Grieve | 159 | 2001 | 25 | ||
| Richie Sexson | 159 | 2000 | 25 | |||
| Jose Canseco | 159 | 1998 | 33 | |||
| Mark McGwire | 159 | 1997 | 33 | |||
| Jay Buhner | 159 | 1996 | 31 | |||
| 34. | Troy Glaus | 158 | 2001 | 24 | ||
| Jeromy Burnitz | 158 | 1998 | 29 | |||
| Melvin Nieves | 158 | 1996 | 24 | |||
| Jose Canseco | 158 | 1990 | 25 | |||
| Andres Galarraga | 158 | 1989 | 27 | |||
| Rob Deer | 158 | 1989 | 28 | |||
| Bo Jackson | 158 | 1987 | 24 | |||
| 35. | Alfonso Soriano | 157 | 2002 | 26 | ||
| Lee Stevens | 157 | 2001 | 33 | |||
| Melvin Nieves | 157 | 1997 | 25 | |||
| Andres Galarraga | 157 | 1996 | 34 | |||
| Jim Presley | 157 | 1987 | 25 | |||
| Jose Canseco | 157 | 1987 | 22 | |||
| Danny Tartabull | 157 | 1986 | 23 | |||
| 36. | Jason Bay | 156 | 2006 | 27 | ||
| Preston Wilson | 156 | 1999 | 24 | |||
| Danny Tartabull | 156 | 1993 | 30 | |||
| Tony Armas | 156 | 1984 | 30 | |||
| Reggie Jackson* | 156 | 1982 | 36 |