| Rank | Player | Wins | Years | ||
| 1. | Cy Young* | 749 | 1890-1911 | ||
| 2. | Pud Galvin* | 646 | 1875-1892 | ||
| 3. | Tim Keefe* | 554 | 1880-1893 | ||
| 4. | Kid Nichols* | 531 | 1890-1906 | ||
| Walter Johnson* | 531 | 1907-1927 | |||
| 5. | Bobby Mathews | 525 | 1871-1887 | ||
| Mickey Welch* | 525 | 1880-1892 | |||
| 6. | Charley Radbourn* | 489 | 1881-1891 | ||
| 7. | John Clarkson* | 485 | 1882-1894 | ||
| 8. | Tony Mullane | 468 | 1881-1894 | ||
| 9. | Jim McCormick | 466 | 1878-1887 | ||
| 10. | Gus Weyhing | 448 | 1887-1901 | ||
| 11. | Pete Alexander* | 437 | 1911-1930 | ||
| 12. | Christy Mathewson* | 434 | 1900-1916 | ||
| 13. | Jack Powell | 422 | 1897-1912 | ||
| 14. | Eddie Plank* | 410 | 1901-1917 | ||
| 15. | Will White | 394 | 1877-1886 | ||
| 16. | Amos Rusie* | 392 | 1889-1901 | ||
| 17. | Vic Willis* | 388 | 1898-1910 | ||
| 18. | Tommy Bond | 386 | 1874-1884 | ||
| 19. | Warren Spahn* | 382 | 1942-1965 | ||
| 20. | Jim Whitney | 377 | 1881-1890 | ||
| 21. | Adonis Terry | 367 | 1884-1897 | ||
| 22. | Ted Lyons* | 356 | 1923-1946 | ||
| 23. | George Mullin | 353 | 1902-1915 | ||
| 24. | Charlie Buffinton | 351 | 1882-1892 | ||
| 25. | Chick Fraser | 342 | 1896-1909 | ||
| 26. | Clark Griffith* | 337 | 1891-1914 | ||
| 27. | Red Ruffing* | 335 | 1924-1947 | ||
| 28. | Silver King | 328 | 1886-1897 | ||
| 29. | Al Orth | 324 | 1895-1909 | ||
| 30. | Bill Hutchison | 321 | 1884-1897 | ||
| 31. | Joe McGinnity* | 314 | 1899-1908 | ||
| Burleigh Grimes* | 314 | 1916-1934 | |||
| 32. | Red Donahue | 312 | 1893-1906 | ||
| 33. | Guy Hecker | 310 | 1882-1890 | ||
| 34. | Bill Dineen | 306 | 1898-1909 | ||
| 35. | Robin Roberts* | 305 | 1948-1966 | ||
| 36. | Gaylord Perry* | 303 | 1962-1983 | ||
| 37. | George Bradley | 302 | 1875-1884 | ||
| 38. | Ted Breitenstein | 300 | 1891-1901 | ||
| 39. | Bob Caruthers | 298 | 1884-1892 | ||
| Lefty Grove* | 298 | 1925-1941 | |||
| 40. | Ed Morris | 297 | 1884-1890 | ||
| Pink Hawley | 297 | 1892-1901 | |||
| 41. | Mark Baldwin | 296 | 1887-1893 | ||
| 42. | Brickyard Kennedy | 293 | 1892-1903 | ||
| 43. | Eppa Rixey* | 290 | 1912-1933 | ||
| Early Wynn* | 290 | 1939-1963 | |||
| 44. | Bill Donovan | 289 | 1898-1918 | ||
| 45. | Bert Cunningham | 286 | 1887-1901 | ||
| 46. | Al Spalding* | 281 | 1871-1877 | ||
| 47. | Sadie McMahon | 279 | 1889-1897 | ||
| Wilbur Cooper | 279 | 1912-1926 | |||
| Bob Feller* | 279 | 1936-1956 | |||
| 48. | Jack Taylor | 278 | 1898-1907 | ||
| Jack Stivetts | 278 | 1889-1899 | |||
| 49. | Charlie Getzein | 277 | 1884-1892 | ||
| 50. | Red Faber* | 273 | 1914-1933 | ||
| 51. | Mordecai Brown* | 271 | 1903-1916 | ||
| 52. | Jouett Meekin | 270 | 1891-1900 | ||
| Frank Dwyer | 270 | 1888-1899 | |||
| 53. | Fergie Jenkins* | 267 | 1965-1983 | ||
| 54. | Elton Chamberlain | 265 | 1886-1896 | ||
| 55. | Matt Kilroy | 264 | 1886-1898 | ||
| 56. | Jesse Tannehill | 263 | 1894-1911 | ||
| 57. | Doc White | 262 | 1901-1913 | ||
| 58. | Rube Waddell* | 261 | 1897-1910 | ||
| 59. | Jack Chesbro* | 260 | 1899-1909 | ||
| Carl Hubbell* | 260 | 1928-1943 | |||
| Red Ehret | 260 | 1888-1898 | |||
| 60. | Larry Corcoran | 256 | 1880-1887 | ||
| 61. | Chief Bender* | 255 | 1903-1925 | ||
| Bob Gibson* | 255 | 1959-1975 | |||
| 62. | Steve Carlton* | 254 | 1965-1988 | ||
| 63. | Frank Killen | 253 | 1891-1900 | ||
| 64. | Win Mercer | 251 | 1894-1902 | ||
| Paul Derringer | 251 | 1931-1945 | |||
| 65. | Ed Walsh* | 250 | 1904-1917 | ||
| Sam Jones | 250 | 1914-1935 | |||
| 66. | Stump Wiedman | 249 | 1880-1888 | ||
| Eddie Cicotte | 249 | 1905-1920 | |||
| 67. | Herb Pennock* | 247 | 1912-1934 | ||
| 68. | Bobo Newsom | 246 | 1929-1953 | ||
| 69. | Phil Niekro* | 245 | 1964-1987 | ||
| Hooks Dauss | 245 | 1912-1926 | |||
| 70. | Juan Marichal* | 244 | 1960-1975 | ||
| John Ward* | 244 | 1878-1884 | |||
| Harry Howell | 244 | 1898-1910 | |||
| 71. | Jack Quinn | 243 | 1909-1933 | ||
| 72. | Deacon Phillippe | 242 | 1899-1911 | ||
| Bucky Walters | 242 | 1934-1950 | |||
| Bert Blyleven | 242 | 1970-1992 | |||
| 73. | Sam Leever | 241 | 1898-1910 | ||
| 74. | Kid Gleason | 240 | 1888-1895 | ||
| 75. | Addie Joss* | 234 | 1902-1910 | ||
| 76. | Candy Cummings* | 233 | 1872-1877 | ||
| 77. | George Uhle | 232 | 1919-1936 | ||
| 78. | Carl Mays | 231 | 1915-1929 | ||
| Harry Staley | 231 | 1888-1895 |