| Rank | Player | Wins | Years | ||
| 1. | Ed Walsh* | 1.82 | 1904-1917 | ||
| 2. | Addie Joss* | 1.89 | 1902-1910 | ||
| 3. | Jack Pfiester | 2.02 | 1903-1911 | ||
| 4. | Joe Wood | 2.03 | 1908-1920 | ||
| 5. | Jim Devlin | 2.05 | 1875-1877 | ||
| 6. | Mordecai Brown* | 2.06 | 1903-1916 | ||
| 7. | John Ward* | 2.10 | 1878-1884 | ||
| 8. | Christy Mathewson* | 2.13 | 1900-1916 | ||
| 9. | Al Spalding* | 2.14 | 1871-1877 | ||
| 10. | Rube Waddell* | 2.16 | 1897-1910 | ||
| 11. | Walter Johnson* | 2.17 | 1907-1927 | ||
| 12. | Jake Weimer | 2.23 | 1903-1909 | ||
| 13. | Orval Overall | 2.23 | 1905-1913 | ||
| 14. | Will White | 2.28 | 1877-1886 | ||
| 15. | Babe Ruth* | 2.28 | 1914-1933 | ||
| 16. | Ed Reulbach | 2.28 | 1905-1917 | ||
| 17. | Mariano Rivera | 2.29 | 1995-2008 | ||
| 18. | Jim Scott | 2.30 | 1909-1917 | ||
| 19. | Tommy Bond | 2.31 | 1874-1884 | ||
| 20. | Reb Russell | 2.33 | 1913-1919 | ||
| 21. | Andy Coakley | 2.35 | 1902-1911 | ||
| 22. | Eddie Plank* | 2.35 | 1901-1917 | ||
| 23. | Larry Corcoran | 2.36 | 1880-1887 | ||
| 24. | George McQuillan | 2.38 | 1907-1918 | ||
| 25. | Eddie Cicotte | 2.38 | 1905-1920 | ||
| 26. | Ed Killian | 2.38 | 1903-1910 | ||
| 27. | Doc White | 2.39 | 1901-1913 | ||
| 28. | Harry Coveleski | 2.39 | 1907-1918 | ||
| 29. | Carl Lundgren | 2.42 | 1902-1909 | ||
| 30. | George Bradley | 2.42 | 1875-1884 | ||
| 31. | Nap Rucker | 2.42 | 1907-1916 | ||
| 32. | Jeff Tesreau | 2.43 | 1912-1918 | ||
| 33. | Joe Benz | 2.43 | 1911-1919 | ||
| 34. | Jim McCormick | 2.43 | 1878-1887 | ||
| 35. | Terry Larkin | 2.43 | 1876-1880 | ||
| 36. | Chief Bender* | 2.46 | 1903-1925 | ||
| 37. | Hooks Wiltse | 2.47 | 1904-1915 | ||
| 38. | Sam Leever | 2.47 | 1898-1910 | ||
| 39. | Lefty Leifield | 2.47 | 1905-1920 | ||
| 40. | Hippo Vaughn | 2.49 | 1908-1921 | ||
| 41. | Candy Cummings* | 2.49 | 1872-1877 | ||
| 42. | Bob Ewing | 2.49 | 1902-1912 | ||
| 43. | Cy Morgan | 2.51 | 1903-1913 | ||
| 44. | Ray Collins | 2.51 | 1909-1915 | ||
| 45. | Hoyt Wilhelm* | 2.52 | 1952-1972 | ||
| 46. | Lew Richie | 2.54 | 1906-1913 | ||
| 47. | Noodles Hahn | 2.55 | 1899-1906 | ||
| 48. | Frank Owen | 2.55 | 1901-1909 | ||
| 49. | Pete Alexander* | 2.56 | 1911-1930 | ||
| 50. | Slim Sallee | 2.56 | 1908-1921 | ||
| 51. | Deacon Phillippe | 2.59 | 1899-1911 | ||
| 52. | Russ Ford | 2.59 | 1909-1915 | ||
| 53. | Frank Smith | 2.59 | 1904-1915 | ||
| 54. | Ed Siever | 2.60 | 1901-1908 | ||
| 55. | Bob Rhoads | 2.61 | 1902-1909 | ||
| 56. | Fred Glade | 2.62 | 1902-1908 | ||
| 57. | Tim Keefe* | 2.62 | 1880-1893 | ||
| 58. | Cy Young* | 2.63 | 1890-1911 | ||
| 59. | Vic Willis* | 2.63 | 1898-1910 | ||
| 60. | Red Ames | 2.63 | 1903-1919 | ||
| 61. | Barney Pelty | 2.63 | 1903-1912 | ||
| 62. | Nick Altrock | 2.65 | 1898-1924 | ||
| 63. | Claude Hendrix | 2.65 | 1911-1920 | ||
| 64. | Joe McGinnity* | 2.66 | 1899-1908 | ||
| 65. | Dick Rudolph | 2.66 | 1910-1927 | ||
| 66. | Jack Taylor | 2.66 | 1898-1907 | ||
| 67. | Pete Schneider | 2.66 | 1914-1919 | ||
| 68. | Carl Weilman | 2.67 | 1912-1920 | ||
| 69. | Charlie Ferguson | 2.67 | 1884-1887 | ||
| 70. | Charley Radbourn* | 2.67 | 1881-1891 | ||
| 71. | Johnny Lush | 2.68 | 1904-1910 | ||
| 72. | Cy Falkenberg | 2.68 | 1903-1917 | ||
| 73. | Jack Chesbro* | 2.68 | 1899-1909 | ||
| 74. | Fred Toney | 2.69 | 1911-1923 | ||
| 75. | Bill Donovan | 2.69 | 1898-1918 | ||
| 76. | Larry Cheney | 2.70 | 1911-1919 | ||
| 77. | Vean Gregg | 2.70 | 1911-1925 | ||
| 78. | Mickey Welch* | 2.71 | 1880-1892 | ||
| 79. | Ned Garvin | 2.72 | 1896-1904 | ||
| 80. | Bob Wicker | 2.73 | 1901-1906 | ||
| 81. | Fred Goldsmith | 2.73 | 1879-1884 | ||
| 82. | Nick Cullop | 2.73 | 1913-1921 | ||
| 83. | Harry Howell | 2.74 | 1898-1910 | ||
| 84. | Whitey Ford* | 2.75 | 1950-1967 | ||
| 85. | Dummy Taylor | 2.75 | 1900-1908 | ||
| 86. | Howie Camnitz | 2.75 | 1904-1915 | ||
| 87. | Roy Patterson | 2.75 | 1901-1907 | ||
| 88. | Babe Adams | 2.76 | 1906-1926 | ||
| 89. | Dutch Leonard | 2.76 | 1913-1925 | ||
| 90. | Dan Quisenberry | 2.76 | 1979-1990 | ||
| 91. | Sandy Koufax* | 2.76 | 1955-1966 | ||
| 92. | Jeff Pfeffer | 2.77 | 1911-1924 | ||
| 93. | Al Demaree | 2.77 | 1912-1919 | ||
| 94. | Earl Moore | 2.78 | 1901-1914 | ||
| 95. | George Zettlein | 2.78 | 1871-1876 | ||
| 96. | Jack Coombs | 2.78 | 1906-1920 | ||
| 97. | Ed Karger | 2.79 | 1906-1911 | ||
| 98. | Jesse Tannehill | 2.79 | 1894-1911 | ||
| 99. | Ron Perranoski | 2.79 | 1961-1973 | ||
| 100. | Tully Sparks | 2.79 | 1897-1910 |