| Rank | Player | Wins | Years | ||
| 1. | Cy Young* | 2147 | 1890-1911 | ||
| 2. | Phil Niekro* | 2012 | 1964-1987 | ||
| 3. | Don Sutton* | 1914 | 1966-1988 | ||
| 4. | Nolan Ryan* | 1911 | 1966-1993 | ||
| 5. | Pud Galvin* | 1910 | 1875-1892 | ||
| 6. | Gus Weyhing | 1867 | 1887-1901 | ||
| 7. | Steve Carlton* | 1864 | 1965-1988 | ||
| 8. | Gaylord Perry* | 1846 | 1962-1983 | ||
| 9. | Red Ruffing* | 1833 | 1924-1947 | ||
| 10. | Bert Blyleven | 1830 | 1970-1992 | ||
| 11. | Warren Spahn* | 1798 | 1942-1965 | ||
| 12. | Early Wynn* | 1796 | 1939-1963 | ||
| 13. | Robin Roberts* | 1774 | 1948-1966 | ||
| 14. | Greg Maddux | 1756 | 1986-2008 | ||
| 15. | Tommy John | 1749 | 1963-1989 | ||
| 16. | Jamie Moyer | 1743 | 1986-2008 | ||
| 17. | Jim Kaat | 1738 | 1959-1983 | ||
| 18. | Tom Glavine | 1734 | 1987-2008 | ||
| 19. | Earl Whitehill | 1726 | 1923-1939 | ||
| 20. | Roger Clemens | 1707 | 1984-2007 | ||
| 21. | Frank Tanana | 1704 | 1973-1993 | ||
| 22. | Ted Lyons* | 1696 | 1923-1946 | ||
| 23. | Fergie Jenkins* | 1669 | 1965-1983 | ||
| 24. | Bobo Newsom | 1664 | 1929-1953 | ||
| 25. | Kid Nichols* | 1660 | 1890-1906 | ||
| 26. | Jack Morris | 1657 | 1977-1994 | ||
| 27. | Sam Jones | 1656 | 1914-1935 | ||
| 28. | Dennis Martinez | 1643 | 1976-1998 | ||
| 29. | Burleigh Grimes* | 1638 | 1916-1934 | ||
| 30. | Bobby Mathews | 1591 | 1871-1887 | ||
| 31. | Charlie Hough | 1582 | 1970-1994 | ||
| 32. | David Wells | 1578 | 1987-2007 | ||
| 33. | Eppa Rixey* | 1572 | 1912-1933 | ||
| 34. | Kenny Rogers | 1568 | 1989-2008 | ||
| 35. | Tony Mullane | 1537 | 1881-1894 | ||
| 36. | Tom Seaver* | 1521 | 1967-1986 | ||
| 37. | Waite Hoyt* | 1500 | 1918-1938 | ||
| 38. | Jerry Reuss | 1483 | 1969-1990 | ||
| 39. | Pete Alexander* | 1476 | 1911-1930 | ||
| 40. | Tim Keefe* | 1472 | 1880-1893 | ||
| 41. | Randy Johnson | 1461 | 1988-2008 | ||
| 42. | Adonis Terry | 1460 | 1884-1897 | ||
| 43. | Mike Mussina | 1458 | 1991-2008 | ||
| 44. | Jack Powell | 1450 | 1897-1912 | ||
| 45. | Mickey Welch* | 1447 | 1880-1892 | ||
| Mel Harder | 1447 | 1928-1947 | |||
| 46. | Bob Friend | 1438 | 1951-1966 | ||
| 47. | Jerry Koosman | 1433 | 1967-1985 | ||
| Jack Quinn | 1433 | 1909-1933 | |||
| 48. | Joe Niekro | 1431 | 1967-1988 | ||
| 49. | Red Faber* | 1430 | 1914-1933 | ||
| 50. | Herb Pennock* | 1428 | 1912-1934 | ||
| 51. | Walter Johnson* | 1424 | 1907-1927 | ||
| 52. | John Clarkson* | 1417 | 1882-1894 | ||
| 53. | Doyle Alexander | 1406 | 1971-1989 | ||
| 54. | Paul Derringer | 1401 | 1931-1945 | ||
| 55. | Mickey Lolich | 1390 | 1963-1979 | ||
| 56. | Bump Hadley | 1389 | 1926-1941 | ||
| 57. | George Uhle | 1384 | 1919-1936 | ||
| Bob Feller* | 1384 | 1936-1956 | |||
| 58. | Mike Moore | 1381 | 1982-1995 | ||
| 59. | Chick Fraser | 1371 | 1896-1909 | ||
| 60. | Jim Bunning* | 1366 | 1955-1971 | ||
| Chuck Finley | 1366 | 1986-2002 | |||
| 61. | Charley Radbourn* | 1348 | 1881-1891 | ||
| 62. | Tim Wakefield | 1345 | 1992-2008 | ||
| 63. | Mike Torrez | 1340 | 1967-1984 | ||
| 64. | Lefty Grove* | 1339 | 1925-1941 | ||
| 65. | Rick Reuschel | 1330 | 1972-1991 | ||
| Ted Breitenstein | 1330 | 1891-1901 | |||
| 66. | Brickyard Kennedy | 1329 | 1892-1903 | ||
| 67. | Pink Hawley | 1326 | 1892-1901 | ||
| 68. | Bobby Witt | 1324 | 1986-2001 | ||
| 69. | Curt Simmons | 1318 | 1947-1967 | ||
| 70. | Mark Langston | 1306 | 1984-1999 | ||
| 71. | Mike Morgan | 1303 | 1978-2002 | ||
| 72. | Jesse Haines* | 1298 | 1918-1937 | ||
| 73. | Tom Zachary | 1295 | 1918-1936 | ||
| 74. | Amos Rusie* | 1287 | 1889-1901 | ||
| 75. | Danny Darwin | 1286 | 1978-1998 | ||
| 76. | Rick Wise | 1281 | 1964-1982 | ||
| Willis Hudlin | 1281 | 1926-1944 | |||
| 77. | Luis Tiant | 1280 | 1964-1982 | ||
| 78. | Bert Cunningham | 1279 | 1887-1901 | ||
| 79. | Dennis Eckersley* | 1278 | 1975-1998 | ||
| 80. | Charley Root | 1274 | 1923-1941 | ||
| 81. | Claude Osteen | 1268 | 1957-1975 | ||
| John Burkett | 1268 | 1987-2003 | |||
| 82. | Terry Mulholland | 1262 | 1986-2006 | ||
| 83. | Jim Perry | 1258 | 1959-1975 | ||
| Bob Gibson* | 1258 | 1959-1975 | |||
| 84. | Freddie Fitzsimmons | 1257 | 1925-1943 | ||
| 85. | Al Orth | 1256 | 1895-1909 | ||
| 86. | Jim Palmer* | 1253 | 1965-1984 | ||
| Curt Schilling | 1253 | 1988-2007 | |||
| 87. | Catfish Hunter* | 1248 | 1965-1979 | ||
| 88. | Lew Burdette | 1246 | 1950-1967 | ||
| Clark Griffith* | 1246 | 1891-1914 | |||
| 89. | Hooks Dauss | 1245 | 1912-1926 | ||
| 90. | Murry Dickson | 1240 | 1939-1959 |