| Rank | Player | Wins | Years | ||
| 1. | Walter Johnson* | 203 | 1907-1927 | ||
| 2. | Eddie Plank* | 196 | 1901-1917 | ||
| 3. | Randy Johnson | 188 | 1988-2008 | ||
| 4. | Joe McGinnity* | 182 | 1899-1908 | ||
| 5. | Chick Fraser | 177 | 1896-1909 | ||
| 6. | Charlie Hough | 174 | 1970-1994 | ||
| 7. | Tim Wakefield | 163 | 1992-2008 | ||
| Cy Young* | 163 | 1890-1911 | |||
| 8. | Jim Bunning* | 160 | 1955-1971 | ||
| 9. | Roger Clemens | 159 | 1984-2007 | ||
| 10. | Nolan Ryan* | 158 | 1966-1993 | ||
| 11. | Vic Willis* | 157 | 1898-1910 | ||
| 12. | Bert Blyleven | 155 | 1970-1992 | ||
| 13. | Don Drysdale* | 154 | 1956-1969 | ||
| 14. | Kevin Brown | 139 | 1986-2005 | ||
| 15. | Greg Maddux | 137 | 1986-2008 | ||
| Pedro Martinez | 137 | 1992-2008 | |||
| Howard Ehmke | 137 | 1915-1930 | |||
| 16. | Kid Nichols* | 133 | 1890-1906 | ||
| 17. | Ed Doheny | 132 | 1895-1903 | ||
| 18. | George Mullin | 131 | 1902-1915 | ||
| 19. | Chan Ho Park | 130 | 1994-2008 | ||
| Jesse Tannehill | 130 | 1894-1911 | |||
| 20. | Dave Stieb | 129 | 1979-1998 | ||
| Frank Tanana | 129 | 1973-1993 | |||
| 21. | Jamie Moyer | 128 | 1986-2008 | ||
| 22. | Kenny Rogers | 127 | 1989-2008 | ||
| Jamey Wright | 127 | 1996-2008 | |||
| 23. | Willie Sudhoff | 126 | 1897-1906 | ||
| 24. | Jeff Weaver | 124 | 1999-2008 | ||
| 25. | Phil Niekro* | 123 | 1964-1987 | ||
| 26. | Jim Kaat | 122 | 1959-1983 | ||
| Dennis Martinez | 122 | 1976-1998 | |||
| 27. | Jack Powell | 121 | 1897-1912 | ||
| Hooks Dauss | 121 | 1912-1926 | |||
| 28. | Doc White | 119 | 1901-1913 | ||
| 29. | Darryl Kile | 117 | 1991-2002 | ||
| Al Leiter | 117 | 1987-2005 | |||
| Rube Waddell* | 117 | 1897-1910 | |||
| Orel Hershiser | 117 | 1983-2000 | |||
| 30. | Jack Warhop | 114 | 1908-1915 | ||
| 31. | George Uhle | 113 | 1919-1936 | ||
| Jack Chesbro* | 113 | 1899-1909 | |||
| 32. | Aaron Sele | 112 | 1993-2007 | ||
| 33. | Pedro Astacio | 111 | 1992-2006 | ||
| 34. | Gus Weyhing | 109 | 1887-1901 | ||
| 35. | Gaylord Perry* | 108 | 1962-1983 | ||
| 36. | Ed Reulbach | 107 | 1905-1917 | ||
| Barney Pelty | 107 | 1903-1912 | |||
| 37. | Earl Moore | 106 | 1901-1914 | ||
| Ed Willett | 106 | 1906-1915 | |||
| David Cone | 106 | 1986-2003 | |||
| 38. | Jim Lonborg | 105 | 1965-1979 | ||
| Jeff Pfeffer | 105 | 1911-1924 | |||
| 39. | Tom Hughes | 104 | 1900-1913 | ||
| 40. | Red Faber* | 103 | 1914-1933 | ||
| Scott Erickson | 103 | 1990-2006 | |||
| 41. | Chief Bender* | 102 | 1903-1925 | ||
| Clark Griffith* | 102 | 1891-1914 | |||
| Bob Gibson* | 102 | 1959-1975 | |||
| 42. | Earl Whitehill | 101 | 1923-1939 | ||
| Red Donahue | 101 | 1893-1906 | |||
| 43. | Wilbur Cooper | 100 | 1912-1926 | ||
| 44. | Don Cardwell | 98 | 1957-1970 | ||
| Jack Billingham | 98 | 1968-1980 | |||
| Pink Hawley | 98 | 1892-1901 | |||
| Tommy John | 98 | 1963-1989 | |||
| 45. | Frank Lary | 97 | 1954-1965 | ||
| Burleigh Grimes* | 97 | 1916-1934 | |||
| Harry Howell | 97 | 1898-1910 | |||
| 46. | Tim Keefe* | 96 | 1880-1893 | ||
| Harry McIntire | 96 | 1905-1913 | |||
| Togie Pittinger | 96 | 1900-1907 | |||
| 47. | Cy Morgan | 95 | 1903-1913 | ||
| Rube Benton | 95 | 1910-1925 | |||
| 48. | Jack Quinn | 94 | 1909-1933 | ||
| Julian Tavarez | 94 | 1993-2008 | |||
| Kerry Wood | 94 | 1998-2008 | |||
| Matt Clement | 94 | 1998-2006 | |||
| 49. | Mickey Lolich | 92 | 1963-1979 | ||
| Win Mercer | 92 | 1894-1902 | |||
| Jack Taylor | 92 | 1898-1907 | |||
| 50. | Vicente Padilla | 91 | 1999-2008 | ||
| Bill Donovan | 91 | 1898-1918 | |||
| 51. | Lee Meadows | 90 | 1915-1929 | ||
| Sam Leever | 90 | 1898-1910 | |||
| John Burkett | 90 | 1987-2003 | |||
| Joe Coleman | 90 | 1965-1979 | |||
| 52. | Carl Mays | 89 | 1915-1929 | ||
| 53. | Jakie May | 88 | 1917-1932 | ||
| Tully Sparks | 88 | 1897-1910 | |||
| Rick Reuschel | 88 | 1972-1991 | |||
| Jack Coombs | 88 | 1906-1920 | |||
| 54. | Mike Boddicker | 87 | 1980-1993 | ||
| 55. | Nixey Callahan | 86 | 1894-1903 | ||
| 56. | Lefty Leifield | 85 | 1905-1920 | ||
| Hippo Vaughn | 85 | 1908-1921 | |||
| Tommy Byrne | 85 | 1943-1957 | |||
| Tom Candiotti | 85 | 1983-1999 | |||
| 57. | Cy Seymour | 84 | 1896-1902 |