| Rank | Player | Wins | Years | ||
| 1. | Cy Young* | 7092 | 1890-1911 | ||
| 2. | Pud Galvin* | 6405 | 1875-1892 | ||
| 3. | Bobby Mathews | 5591 | 1871-1887 | ||
| 4. | Phil Niekro* | 5044 | 1964-1987 | ||
| 5. | Gaylord Perry* | 4938 | 1962-1983 | ||
| 6. | Walter Johnson* | 4913 | 1907-1927 | ||
| 7. | Kid Nichols* | 4912 | 1890-1906 | ||
| 8. | Pete Alexander* | 4868 | 1911-1930 | ||
| 9. | Warren Spahn* | 4830 | 1942-1965 | ||
| 10. | Tommy John | 4783 | 1963-1989 | ||
| 11. | Greg Maddux | 4726 | 1986-2008 | ||
| 12. | Don Sutton* | 4692 | 1966-1988 | ||
| 13. | Steve Carlton* | 4672 | 1965-1988 | ||
| 14. | Eppa Rixey* | 4633 | 1912-1933 | ||
| 15. | Bert Blyleven | 4632 | 1970-1992 | ||
| 16. | Jim Kaat | 4620 | 1959-1983 | ||
| 17. | Mickey Welch* | 4587 | 1880-1892 | ||
| 18. | Robin Roberts* | 4582 | 1948-1966 | ||
| 19. | Gus Weyhing | 4562 | 1887-1901 | ||
| 20. | Ted Lyons* | 4489 | 1923-1946 | ||
| 21. | Tim Keefe* | 4439 | 1880-1893 | ||
| 22. | Burleigh Grimes* | 4412 | 1916-1934 | ||
| 23. | Charley Radbourn* | 4335 | 1881-1891 | ||
| 24. | Jack Powell | 4319 | 1897-1912 | ||
| 25. | Tom Glavine | 4298 | 1987-2008 | ||
| 26. | John Clarkson* | 4295 | 1882-1894 | ||
| 27. | Early Wynn* | 4291 | 1939-1963 | ||
| 28. | Red Ruffing* | 4284 | 1924-1947 | ||
| 29. | Jack Quinn | 4238 | 1909-1933 | ||
| 30. | Christy Mathewson* | 4218 | 1900-1916 | ||
| 31. | Tony Mullane | 4195 | 1881-1894 | ||
| 32. | Roger Clemens | 4185 | 1984-2007 | ||
| 33. | Fergie Jenkins* | 4142 | 1965-1983 | ||
| 34. | Red Faber* | 4106 | 1914-1933 | ||
| 35. | Jim McCormick | 4092 | 1878-1887 | ||
| 36. | Sam Jones | 4084 | 1914-1935 | ||
| 37. | Frank Tanana | 4063 | 1973-1993 | ||
| 38. | Waite Hoyt* | 4037 | 1918-1938 | ||
| 39. | Tom Seaver* | 3971 | 1967-1986 | ||
| 40. | Eddie Plank* | 3958 | 1901-1917 | ||
| 41. | Nolan Ryan* | 3923 | 1966-1993 | ||
| 42. | Earl Whitehill | 3917 | 1923-1939 | ||
| 43. | Paul Derringer | 3912 | 1931-1945 | ||
| 44. | Herb Pennock* | 3900 | 1912-1934 | ||
| 45. | Dennis Martinez | 3897 | 1976-1998 | ||
| 46. | Jamie Moyer | 3876 | 1986-2008 | ||
| 47. | Lefty Grove* | 3849 | 1925-1941 | ||
| 48. | Bob Friend | 3772 | 1951-1966 | ||
| 49. | Bobo Newsom | 3769 | 1929-1953 | ||
| 50. | Tommy Bond | 3767 | 1874-1884 | ||
| 51. | Jerry Reuss | 3734 | 1969-1990 | ||
| 52. | Mel Harder | 3706 | 1928-1947 | ||
| 53. | Clark Griffith* | 3670 | 1891-1914 | ||
| 54. | Jerry Koosman | 3635 | 1967-1985 | ||
| David Wells | 3635 | 1987-2007 | |||
| 55. | Vic Willis* | 3621 | 1898-1910 | ||
| 56. | Jim Whitney | 3598 | 1881-1890 | ||
| 57. | Rick Reuschel | 3588 | 1972-1991 | ||
| 58. | Tom Zachary | 3580 | 1918-1936 | ||
| 59. | Jack Morris | 3567 | 1977-1994 | ||
| 60. | Al Orth | 3564 | 1895-1909 | ||
| 61. | Adonis Terry | 3525 | 1884-1897 | ||
| 62. | George Mullin | 3518 | 1902-1915 | ||
| 63. | Claude Osteen | 3471 | 1957-1975 | ||
| 64. | Joe Niekro | 3466 | 1967-1988 | ||
| 65. | Carl Hubbell* | 3461 | 1928-1943 | ||
| 66. | Mike Mussina | 3460 | 1991-2008 | ||
| Chick Fraser | 3460 | 1896-1909 | |||
| Jesse Haines* | 3460 | 1918-1937 | |||
| 67. | Kenny Rogers | 3457 | 1989-2008 | ||
| 68. | Will White | 3440 | 1877-1886 | ||
| 69. | Jim Bunning* | 3433 | 1955-1971 | ||
| 70. | George Uhle | 3417 | 1919-1936 | ||
| 71. | Wilbur Cooper | 3415 | 1912-1926 | ||
| 72. | Hooks Dauss | 3407 | 1912-1926 | ||
| 73. | Amos Rusie* | 3384 | 1889-1901 | ||
| 74. | Doyle Alexander | 3376 | 1971-1989 | ||
| Red Donahue | 3376 | 1893-1906 | |||
| 75. | Larry French | 3375 | 1929-1942 | ||
| 76. | Mickey Lolich | 3366 | 1963-1979 | ||
| 77. | Jim Palmer* | 3349 | 1965-1984 | ||
| 78. | Charlie Buffinton | 3344 | 1882-1892 | ||
| 79. | Freddie Fitzsimmons | 3335 | 1925-1943 | ||
| 80. | Pink Hawley | 3334 | 1892-1901 | ||
| 81. | Curt Simmons | 3313 | 1947-1967 | ||
| 82. | Dutch Leonard | 3304 | 1933-1953 | ||
| 83. | Frank Dwyer | 3301 | 1888-1899 | ||
| 84. | Charlie Hough | 3283 | 1970-1994 | ||
| 85. | Lee Meadows | 3280 | 1915-1929 | ||
| 86. | Bob Gibson* | 3279 | 1959-1975 | ||
| 87. | Joe McGinnity* | 3276 | 1899-1908 | ||
| Brickyard Kennedy | 3276 | 1892-1903 | |||
| 88. | Al Spalding* | 3271 | 1871-1877 | ||
| Bob Feller* | 3271 | 1936-1956 | |||
| 89. | Charley Root | 3252 | 1923-1941 | ||
| 90. | Randy Johnson | 3249 | 1988-2008 | ||
| 91. | Rube Marquard* | 3233 | 1908-1925 | ||
| 92. | Dolf Luque | 3231 | 1914-1935 | ||
| 93. | Rick Wise | 3227 | 1964-1982 | ||
| 94. | Larry Jackson | 3206 | 1955-1968 |