| Rank | Player | Wins | Years | ||
| 1. | Robin Roberts* | 505 | 1948-1966 | ||
| 2. | Fergie Jenkins* | 484 | 1965-1983 | ||
| 3. | Phil Niekro* | 482 | 1964-1987 | ||
| 4. | Don Sutton* | 472 | 1966-1988 | ||
| 5. | Jamie Moyer | 464 | 1986-2008 | ||
| 6. | Frank Tanana | 448 | 1973-1993 | ||
| 7. | Warren Spahn* | 434 | 1942-1965 | ||
| 8. | Bert Blyleven | 430 | 1970-1992 | ||
| 9. | Steve Carlton* | 414 | 1965-1988 | ||
| 10. | David Wells | 407 | 1987-2007 | ||
| 11. | Gaylord Perry* | 399 | 1962-1983 | ||
| 12. | Jim Kaat | 395 | 1959-1983 | ||
| 13. | Randy Johnson | 392 | 1988-2008 | ||
| 14. | Jack Morris | 389 | 1977-1994 | ||
| 15. | Charlie Hough | 383 | 1970-1994 | ||
| 16. | Tom Seaver* | 380 | 1967-1986 | ||
| 17. | Mike Mussina | 376 | 1991-2008 | ||
| 18. | Catfish Hunter* | 374 | 1965-1979 | ||
| 19. | Dennis Martinez | 372 | 1976-1998 | ||
| Jim Bunning* | 372 | 1955-1971 | |||
| 20. | Roger Clemens | 363 | 1984-2007 | ||
| 21. | Tim Wakefield | 362 | 1992-2008 | ||
| 22. | Tom Glavine | 356 | 1987-2008 | ||
| 23. | Greg Maddux | 353 | 1986-2008 | ||
| 24. | Steve Trachsel | 348 | 1993-2008 | ||
| 25. | Mickey Lolich | 347 | 1963-1979 | ||
| Curt Schilling | 347 | 1988-2007 | |||
| Dennis Eckersley* | 347 | 1975-1998 | |||
| 26. | Luis Tiant | 346 | 1964-1982 | ||
| 27. | Kenny Rogers | 339 | 1989-2008 | ||
| 28. | Early Wynn* | 338 | 1939-1963 | ||
| 29. | Brad Radke | 326 | 1995-2006 | ||
| 30. | Doyle Alexander | 324 | 1971-1989 | ||
| 31. | Nolan Ryan* | 321 | 1966-1993 | ||
| Danny Darwin | 321 | 1978-1998 | |||
| 32. | Juan Marichal* | 320 | 1960-1975 | ||
| 33. | Pedro Ramos | 315 | 1955-1970 | ||
| 34. | Mark Langston | 311 | 1984-1999 | ||
| 35. | Jim Perry | 308 | 1959-1975 | ||
| 36. | Chuck Finley | 304 | 1986-2002 | ||
| 37. | Jim Palmer* | 303 | 1965-1984 | ||
| 38. | Murry Dickson | 302 | 1939-1959 | ||
| Tommy John | 302 | 1963-1989 | |||
| 39. | Javier Vazquez | 300 | 1998-2008 | ||
| 40. | Milt Pappas | 298 | 1957-1973 | ||
| 41. | Scott Sanderson | 297 | 1978-1996 | ||
| 42. | Livan Hernandez | 296 | 1996-2008 | ||
| 43. | Jeff Suppan | 295 | 1995-2008 | ||
| 44. | Frank Viola | 294 | 1982-1996 | ||
| 45. | Terry Mulholland | 293 | 1986-2006 | ||
| 46. | Mudcat Grant | 292 | 1958-1971 | ||
| 47. | Mike Moore | 291 | 1982-1995 | ||
| Pedro Astacio | 291 | 1992-2006 | |||
| Floyd Bannister | 291 | 1977-1992 | |||
| 48. | Jerry Koosman | 290 | 1967-1985 | ||
| 49. | Lew Burdette | 289 | 1950-1967 | ||
| Andy Benes | 289 | 1989-2002 | |||
| 50. | Woody Williams | 288 | 1993-2007 | ||
| 51. | Bob Friend | 286 | 1951-1966 | ||
| 52. | Jon Lieber | 285 | 1994-2008 | ||
| 53. | Billy Pierce | 284 | 1945-1964 | ||
| 54. | Bill Gullickson | 282 | 1979-1994 | ||
| 55. | Don Drysdale* | 280 | 1956-1969 | ||
| 56. | Jim Slaton | 277 | 1971-1986 | ||
| John Smoltz | 277 | 1988-2008 | |||
| 57. | Joe Niekro | 276 | 1967-1988 | ||
| 58. | Mike Morgan | 270 | 1978-2002 | ||
| 59. | Pat Hentgen | 269 | 1991-2004 | ||
| 60. | Vern Law | 268 | 1950-1967 | ||
| 61. | Jose Lima | 267 | 1994-2006 | ||
| Bob Welch | 267 | 1978-1994 | |||
| 62. | Eric Milton | 265 | 1998-2007 | ||
| 63. | Dave Stewart | 264 | 1978-1995 | ||
| Brian Anderson | 264 | 1993-2005 | |||
| Tim Belcher | 264 | 1987-2000 | |||
| 64. | Vida Blue | 263 | 1969-1986 | ||
| 65. | Greg Swindell | 262 | 1986-2002 | ||
| 66. | Rick Wise | 261 | 1964-1982 | ||
| 67. | Kevin Tapani | 260 | 1989-2001 | ||
| 68. | Esteban Loaiza | 259 | 1995-2008 | ||
| Larry Jackson | 259 | 1955-1968 | |||
| 69. | David Cone | 258 | 1986-2003 | ||
| Bruce Hurst | 258 | 1980-1994 | |||
| 70. | John Burkett | 257 | 1987-2003 | ||
| Bob Gibson* | 257 | 1959-1975 | |||
| 71. | Camilo Pascual | 256 | 1954-1971 | ||
| 72. | Mike McCormick | 255 | 1956-1971 | ||
| Curt Simmons | 255 | 1947-1967 | |||
| 73. | Jimmy Key | 254 | 1984-1998 | ||
| Red Ruffing* | 254 | 1924-1947 | |||
| 74. | Don Newcombe | 252 | 1949-1960 | ||
| Bobby Witt | 252 | 1986-2001 | |||
| 75. | Hideo Nomo | 251 | 1995-2008 | ||
| Mike Flanagan | 251 | 1975-1992 | |||
| 76. | Denny Neagle | 250 | 1991-2003 | ||
| Tom Candiotti | 250 | 1983-1999 | |||
| 77. | Claude Osteen | 249 | 1957-1975 | ||
| Ken Holtzman | 249 | 1965-1979 | |||
| 78. | Steve Renko | 248 | 1969-1983 | ||
| 79. | Rick Helling | 247 | 1994-2006 |