| Rank | Player | Wins | Years | ||
| 1. | Cy Young* | 7354.2 | 1890-1911 | ||
| 2. | Pud Galvin* | 6003.1 | 1875-1892 | ||
| 3. | Walter Johnson* | 5914.2 | 1907-1927 | ||
| 4. | Phil Niekro* | 5404.1 | 1964-1987 | ||
| 5. | Nolan Ryan* | 5386.0 | 1966-1993 | ||
| 6. | Gaylord Perry* | 5350.1 | 1962-1983 | ||
| 7. | Don Sutton* | 5282.1 | 1966-1988 | ||
| 8. | Warren Spahn* | 5243.2 | 1942-1965 | ||
| 9. | Steve Carlton* | 5217.1 | 1965-1988 | ||
| 10. | Pete Alexander* | 5190.0 | 1911-1930 | ||
| 11. | Kid Nichols* | 5056.1 | 1890-1906 | ||
| 12. | Tim Keefe* | 5047.2 | 1880-1893 | ||
| 13. | Greg Maddux | 5008.1 | 1986-2008 | ||
| 14. | Bert Blyleven | 4970.0 | 1970-1992 | ||
| 15. | Bobby Mathews | 4956.1 | 1871-1887 | ||
| 16. | Roger Clemens | 4916.2 | 1984-2007 | ||
| 17. | Mickey Welch* | 4802.0 | 1880-1892 | ||
| 18. | Tom Seaver* | 4782.2 | 1967-1986 | ||
| 19. | Christy Mathewson* | 4780.2 | 1900-1916 | ||
| 20. | Tommy John | 4710.1 | 1963-1989 | ||
| 21. | Robin Roberts* | 4688.2 | 1948-1966 | ||
| 22. | Early Wynn* | 4564.0 | 1939-1963 | ||
| 23. | John Clarkson* | 4536.1 | 1882-1894 | ||
| 24. | Charley Radbourn* | 4535.1 | 1881-1891 | ||
| 25. | Tony Mullane | 4531.1 | 1881-1894 | ||
| 26. | Jim Kaat | 4530.1 | 1959-1983 | ||
| 27. | Fergie Jenkins* | 4500.2 | 1965-1983 | ||
| 28. | Eddie Plank* | 4495.2 | 1901-1917 | ||
| 29. | Eppa Rixey* | 4494.2 | 1912-1933 | ||
| 30. | Tom Glavine | 4413.1 | 1987-2008 | ||
| 31. | Jack Powell | 4389.0 | 1897-1912 | ||
| 32. | Red Ruffing* | 4344.0 | 1924-1947 | ||
| 33. | Gus Weyhing | 4324.1 | 1887-1901 | ||
| 34. | Jim McCormick | 4275.2 | 1878-1887 | ||
| 35. | Frank Tanana | 4188.1 | 1973-1993 | ||
| 36. | Burleigh Grimes* | 4180.0 | 1916-1934 | ||
| 37. | Ted Lyons* | 4161.0 | 1923-1946 | ||
| 38. | Red Faber* | 4086.2 | 1914-1933 | ||
| 39. | Randy Johnson | 4039.1 | 1988-2008 | ||
| 40. | Dennis Martinez | 3999.2 | 1976-1998 | ||
| 41. | Vic Willis* | 3996.0 | 1898-1910 | ||
| 42. | Jim Palmer* | 3948.0 | 1965-1984 | ||
| 43. | Lefty Grove* | 3940.2 | 1925-1941 | ||
| 44. | Jack Quinn | 3920.1 | 1909-1933 | ||
| 45. | Bob Gibson* | 3884.1 | 1959-1975 | ||
| 46. | Sam Jones | 3883.0 | 1914-1935 | ||
| 47. | Jerry Koosman | 3839.1 | 1967-1985 | ||
| 48. | Bob Feller* | 3827.0 | 1936-1956 | ||
| 49. | Jack Morris | 3824.0 | 1977-1994 | ||
| 50. | Charlie Hough | 3801.1 | 1970-1994 | ||
| 51. | Amos Rusie* | 3769.2 | 1889-1901 | ||
| 52. | Waite Hoyt* | 3762.1 | 1918-1938 | ||
| 53. | Jim Bunning* | 3760.1 | 1955-1971 | ||
| 54. | Bobo Newsom | 3759.1 | 1929-1953 | ||
| 55. | Jamie Moyer | 3746.2 | 1986-2008 | ||
| 56. | George Mullin | 3686.2 | 1902-1915 | ||
| 57. | Jerry Reuss | 3669.2 | 1969-1990 | ||
| 58. | Paul Derringer | 3645.0 | 1931-1945 | ||
| 59. | Mickey Lolich | 3638.1 | 1963-1979 | ||
| 60. | Tommy Bond | 3628.2 | 1874-1884 | ||
| 61. | Bob Friend | 3611.0 | 1951-1966 | ||
| 62. | Carl Hubbell* | 3590.1 | 1928-1943 | ||
| 63. | Joe Niekro | 3584.0 | 1967-1988 | ||
| 64. | Herb Pennock* | 3571.2 | 1912-1934 | ||
| 65. | Earl Whitehill | 3564.2 | 1923-1939 | ||
| 66. | Mike Mussina | 3562.2 | 1991-2008 | ||
| 67. | Rick Reuschel | 3548.1 | 1972-1991 | ||
| 68. | Will White | 3542.2 | 1877-1886 | ||
| 69. | Adonis Terry | 3514.1 | 1884-1897 | ||
| 70. | Juan Marichal* | 3507.1 | 1960-1975 | ||
| 71. | Jim Whitney | 3496.1 | 1881-1890 | ||
| 72. | Luis Tiant | 3486.1 | 1964-1982 | ||
| 73. | Wilbur Cooper | 3480.0 | 1912-1926 | ||
| 74. | Claude Osteen | 3460.1 | 1957-1975 | ||
| 75. | Catfish Hunter* | 3449.1 | 1965-1979 | ||
| 76. | Joe McGinnity* | 3441.1 | 1899-1908 | ||
| 77. | David Wells | 3439.0 | 1987-2007 | ||
| 78. | Don Drysdale* | 3432.0 | 1956-1969 | ||
| 79. | Mel Harder | 3426.1 | 1928-1947 | ||
| 80. | Charlie Buffinton | 3404.0 | 1882-1892 | ||
| 81. | John Smoltz | 3395.0 | 1988-2008 | ||
| 82. | Hooks Dauss | 3390.2 | 1912-1926 | ||
| 83. | Clark Griffith* | 3385.2 | 1891-1914 | ||
| 84. | Doyle Alexander | 3367.2 | 1971-1989 | ||
| 85. | Chick Fraser | 3356.0 | 1896-1909 | ||
| 86. | Al Orth | 3354.2 | 1895-1909 | ||
| 87. | Curt Simmons | 3348.1 | 1947-1967 | ||
| 88. | Vida Blue | 3343.1 | 1969-1986 | ||
| 89. | Rube Marquard* | 3306.2 | 1908-1925 | ||
| Billy Pierce | 3306.2 | 1945-1964 | |||
| 90. | Kenny Rogers | 3302.2 | 1989-2008 | ||
| 91. | Jim Perry | 3285.2 | 1959-1975 | ||
| Dennis Eckersley* | 3285.2 | 1975-1998 | |||
| 92. | Larry Jackson | 3262.2 | 1955-1968 | ||
| 93. | Curt Schilling | 3261.0 | 1988-2007 | ||
| 94. | Kevin Brown | 3256.1 | 1986-2005 | ||
| 95. | Freddie Fitzsimmons | 3223.2 | 1925-1943 | ||
| 96. | Eddie Cicotte | 3223.1 | 1905-1920 | ||
| 97. | Dolf Luque | 3220.1 | 1914-1935 | ||
| 98. | Dutch Leonard | 3218.1 | 1933-1953 |