| Rank | Player | Wins | Years | ||
| 1. | Cy Young* | 316 | 1890-1911 | ||
| 2. | Pud Galvin* | 310 | 1875-1892 | ||
| 3. | Nolan Ryan* | 292 | 1966-1993 | ||
| 4. | Walter Johnson* | 279 | 1907-1927 | ||
| 5. | Phil Niekro* | 274 | 1964-1987 | ||
| 6. | Gaylord Perry* | 265 | 1962-1983 | ||
| 7. | Don Sutton* | 256 | 1966-1988 | ||
| 8. | Jack Powell | 254 | 1897-1912 | ||
| 9. | Eppa Rixey* | 251 | 1912-1933 | ||
| 10. | Bert Blyleven | 250 | 1970-1992 | ||
| 11. | Bobby Mathews | 248 | 1871-1887 | ||
| 12. | Warren Spahn* | 245 | 1942-1965 | ||
| Robin Roberts* | 245 | 1948-1966 | |||
| 13. | Early Wynn* | 244 | 1939-1963 | ||
| Steve Carlton* | 244 | 1965-1988 | |||
| 14. | Jim Kaat | 237 | 1959-1983 | ||
| 15. | Frank Tanana | 236 | 1973-1993 | ||
| 16. | Gus Weyhing | 232 | 1887-1901 | ||
| 17. | Tommy John | 231 | 1963-1989 | ||
| 18. | Ted Lyons* | 230 | 1923-1946 | ||
| Bob Friend | 230 | 1951-1966 | |||
| 19. | Greg Maddux | 227 | 1986-2008 | ||
| 20. | Fergie Jenkins* | 226 | 1965-1983 | ||
| 21. | Tim Keefe* | 225 | 1880-1893 | ||
| Red Ruffing* | 225 | 1924-1947 | |||
| 22. | Bobo Newsom | 222 | 1929-1953 | ||
| 23. | Tony Mullane | 220 | 1881-1894 | ||
| 24. | Jack Quinn | 218 | 1909-1933 | ||
| 25. | Sam Jones | 217 | 1914-1935 | ||
| 26. | Charlie Hough | 216 | 1970-1994 | ||
| 27. | Jim McCormick | 214 | 1878-1887 | ||
| 28. | Red Faber* | 213 | 1914-1933 | ||
| 29. | Paul Derringer | 212 | 1931-1945 | ||
| Chick Fraser | 212 | 1896-1909 | |||
| Burleigh Grimes* | 212 | 1916-1934 | |||
| 30. | Mickey Welch* | 210 | 1880-1892 | ||
| 31. | Jerry Koosman | 209 | 1967-1985 | ||
| 32. | Kid Nichols* | 208 | 1890-1906 | ||
| Pete Alexander* | 208 | 1911-1930 | |||
| 33. | Tom Seaver* | 205 | 1967-1986 | ||
| Vic Willis* | 205 | 1898-1910 | |||
| 34. | Joe Niekro | 204 | 1967-1988 | ||
| Jim Whitney | 204 | 1881-1890 | |||
| 35. | Tom Glavine | 203 | 1987-2008 | ||
| 36. | George Mullin | 196 | 1902-1915 | ||
| Adonis Terry | 196 | 1884-1897 | |||
| 37. | Claude Osteen | 195 | 1957-1975 | ||
| Charley Radbourn* | 195 | 1881-1891 | |||
| 38. | Eddie Plank* | 194 | 1901-1917 | ||
| 39. | Dennis Martinez | 193 | 1976-1998 | ||
| 40. | Mickey Lolich | 191 | 1963-1979 | ||
| Jerry Reuss | 191 | 1969-1990 | |||
| Rick Reuschel | 191 | 1972-1991 | |||
| Tom Zachary | 191 | 1918-1936 | |||
| 41. | Al Orth | 189 | 1895-1909 | ||
| 42. | Christy Mathewson* | 188 | 1900-1916 | ||
| 43. | Jack Morris | 186 | 1977-1994 | ||
| Mike Morgan | 186 | 1978-2002 | |||
| Mel Harder | 186 | 1928-1947 | |||
| 44. | Jamie Moyer | 185 | 1986-2008 | ||
| Earl Whitehill | 185 | 1923-1939 | |||
| 45. | Roger Clemens | 184 | 1984-2007 | ||
| Jim Bunning* | 184 | 1955-1971 | |||
| 46. | Curt Simmons | 183 | 1947-1967 | ||
| Joe Bush | 183 | 1912-1928 | |||
| Larry Jackson | 183 | 1955-1968 | |||
| 47. | Hooks Dauss | 182 | 1912-1926 | ||
| Danny Darwin | 182 | 1978-1998 | |||
| Waite Hoyt* | 182 | 1918-1938 | |||
| 48. | Dutch Leonard | 181 | 1933-1953 | ||
| Rick Wise | 181 | 1964-1982 | |||
| Murry Dickson | 181 | 1939-1959 | |||
| 49. | Lee Meadows | 180 | 1915-1929 | ||
| 50. | Dolf Luque | 179 | 1914-1935 | ||
| Pink Hawley | 179 | 1892-1901 | |||
| 51. | Wilbur Cooper | 178 | 1912-1926 | ||
| John Clarkson* | 178 | 1882-1894 | |||
| 52. | Rube Marquard* | 177 | 1908-1925 | ||
| Bill Dineen | 177 | 1898-1909 | |||
| 53. | Mike Moore | 176 | 1982-1995 | ||
| 54. | Tom Hughes | 175 | 1900-1913 | ||
| Red Donahue | 175 | 1893-1906 | |||
| 55. | Amos Rusie* | 174 | 1889-1901 | ||
| Jim Perry | 174 | 1959-1975 | |||
| Doyle Alexander | 174 | 1971-1989 | |||
| Bob Gibson* | 174 | 1959-1975 | |||
| 56. | Chuck Finley | 173 | 1986-2002 | ||
| 57. | Luis Tiant | 172 | 1964-1982 | ||
| 58. | Larry French | 171 | 1929-1942 | ||
| Dennis Eckersley* | 171 | 1975-1998 | |||
| 59. | Camilo Pascual | 170 | 1954-1971 | ||
| Ted Breitenstein | 170 | 1891-1901 | |||
| 60. | Billy Pierce | 169 | 1945-1964 | ||
| 61. | Jim Clancy | 167 | 1977-1991 | ||
| Bert Cunningham | 167 | 1887-1901 | |||
| Red Ames | 167 | 1903-1919 | |||
| Red Ehret | 167 | 1888-1898 | |||
| 62. | George Uhle | 166 | 1919-1936 | ||
| Will White | 166 | 1877-1886 | |||
| Howard Ehmke | 166 | 1915-1930 |