| Rank | Player | Wins | Years | ||
| 1. | Al Spalding* | .796 | 1871-1877 | ||
| 2. | Spud Chandler | .717 | 1937-1947 | ||
| 3. | Dave Foutz | .690 | 1884-1894 | ||
| 4. | Whitey Ford* | .690 | 1950-1967 | ||
| 5. | Bob Caruthers | .688 | 1884-1892 | ||
| 6. | Don Gullett | .686 | 1970-1978 | ||
| 7. | Pedro Martinez | .684 | 1992-2008 | ||
| 8. | Johan Santana | .681 | 2000-2008 | ||
| 9. | Lefty Grove* | .680 | 1925-1941 | ||
| 10. | Joe Wood | .672 | 1908-1920 | ||
| 11. | Babe Ruth* | .671 | 1914-1933 | ||
| 12. | Jay Hughes | .669 | 1898-1902 | ||
| 13. | Roy Oswalt | .668 | 2001-2008 | ||
| 14. | Vic Raschi | .667 | 1946-1955 | ||
| 15. | Bill Hoffer | .667 | 1895-1901 | ||
| 16. | Larry Corcoran | .665 | 1880-1887 | ||
| 17. | Roy Halladay | .665 | 1998-2008 | ||
| 18. | Christy Mathewson* | .665 | 1900-1916 | ||
| 19. | Cliff Lee | .661 | 2002-2008 | ||
| 20. | Sam Leever | .660 | 1898-1910 | ||
| 21. | Roger Clemens | .658 | 1984-2007 | ||
| 22. | Sal Maglie | .657 | 1945-1958 | ||
| 23. | Dick McBride | .656 | 1871-1876 | ||
| 24. | Sandy Koufax* | .655 | 1955-1966 | ||
| 25. | Tim Hudson | .655 | 1999-2008 | ||
| 26. | Johnny Allen | .654 | 1932-1944 | ||
| 27. | Ron Guidry | .651 | 1975-1988 | ||
| 28. | Lefty Gomez* | .649 | 1930-1943 | ||
| 29. | Randy Johnson | .648 | 1988-2008 | ||
| 30. | John Clarkson* | .648 | 1882-1894 | ||
| 31. | Mordecai Brown* | .648 | 1903-1916 | ||
| 32. | Dizzy Dean* | .644 | 1930-1947 | ||
| 33. | Pete Alexander* | .642 | 1911-1930 | ||
| 34. | Hugh Casey | .641 | 1935-1949 | ||
| 35. | Lady Baldwin | .640 | 1884-1890 | ||
| 36. | Tex Hughson | .640 | 1941-1949 | ||
| 37. | Pedro Borbon | .639 | 1969-1980 | ||
| 38. | Mike Mussina | .638 | 1991-2008 | ||
| 39. | Jim Palmer* | .638 | 1965-1984 | ||
| 40. | Jerry Nops | .637 | 1896-1901 | ||
| 41. | Johnny Murphy | .637 | 1932-1947 | ||
| 42. | Kid Nichols* | .634 | 1890-1906 | ||
| 43. | Deacon Phillippe | .634 | 1899-1911 | ||
| 44. | Joe McGinnity* | .634 | 1899-1908 | ||
| 45. | Dwight Gooden | .634 | 1984-2000 | ||
| 46. | Ed Reulbach | .632 | 1905-1917 | ||
| 47. | Mark Mulder | .632 | 2000-2008 | ||
| 48. | Juan Marichal* | .631 | 1960-1975 | ||
| 49. | Lefty Williams | .631 | 1913-1920 | ||
| 50. | Mort Cooper | .631 | 1938-1949 | ||
| 51. | Allie Reynolds | .630 | 1942-1954 | ||
| 52. | Jesse Tannehill | .629 | 1894-1911 | ||
| 53. | Andy Pettitte | .629 | 1995-2008 | ||
| 54. | Ray Kremer | .627 | 1924-1933 | ||
| 55. | Firpo Marberry | .627 | 1923-1936 | ||
| 56. | Eddie Plank* | .627 | 1901-1917 | ||
| 57. | Chief Bender* | .625 | 1903-1925 | ||
| 58. | Don Newcombe | .623 | 1949-1960 | ||
| 59. | Carl Lundgren | .623 | 1902-1909 | ||
| 60. | Nig Cuppy | .623 | 1892-1901 | ||
| 61. | Addie Joss* | .623 | 1902-1910 | ||
| 62. | Fred Goldsmith | .622 | 1879-1884 | ||
| 63. | Doc Crandall | .622 | 1908-1918 | ||
| 64. | Carl Mays | .622 | 1915-1929 | ||
| 65. | Carl Hubbell* | .622 | 1928-1943 | ||
| 66. | Bob Feller* | .621 | 1936-1956 | ||
| 67. | Mel Parnell | .621 | 1947-1956 | ||
| 68. | Monte Pearson | .621 | 1932-1941 | ||
| 69. | John Tudor | .619 | 1979-1990 | ||
| 70. | Clark Griffith* | .619 | 1891-1914 | ||
| 71. | Bob Lemon* | .618 | 1946-1958 | ||
| 72. | Cy Young* | .618 | 1890-1911 | ||
| 73. | Jack Pfiester | .617 | 1903-1911 | ||
| 74. | John Ward* | .617 | 1878-1884 | ||
| 75. | C.C. Sabathia | .616 | 2001-2008 | ||
| 76. | Urban Shocker | .615 | 1916-1928 | ||
| 77. | Jeff Tesreau | .615 | 1912-1918 | ||
| 78. | Jim Maloney | .615 | 1960-1971 | ||
| 79. | Jimmy Key | .614 | 1984-1998 | ||
| 80. | Lon Warneke | .613 | 1930-1945 | ||
| 81. | Charley Radbourn* | .613 | 1881-1891 | ||
| 82. | Joe Heving | .613 | 1930-1945 | ||
| 83. | Carlos Zambrano | .611 | 2001-2008 | ||
| 84. | Gary Nolan | .611 | 1967-1977 | ||
| 85. | Schoolboy Rowe | .610 | 1933-1949 | ||
| 86. | Ferdie Schupp | .610 | 1913-1922 | ||
| 87. | Carl Erskine | .610 | 1948-1959 | ||
| 88. | Greg Maddux | .610 | 1986-2008 | ||
| 89. | Ed Walsh* | .607 | 1904-1917 | ||
| 90. | Charlie Ferguson | .607 | 1884-1887 | ||
| 91. | Bartolo Colon | .607 | 1997-2008 | ||
| 92. | Dave McNally | .607 | 1962-1975 | ||
| 93. | Hooks Wiltse | .607 | 1904-1915 | ||
| 94. | Candy Cummings* | .607 | 1872-1877 | ||
| 95. | David Cone | .606 | 1986-2003 | ||
| 96. | Jack Stivetts | .606 | 1889-1899 | ||
| 97. | Ramon Martinez | .605 | 1988-2001 | ||
| 98. | Art Nehf | .605 | 1915-1929 | ||
| 99. | Charlie Buffinton | .605 | 1882-1892 | ||
| 100. | Freddy Garcia | .605 | 1999-2008 |