| Rank | Player | Wins | Years | ||
| 1. | Bobby Mathews | 3497 | 1871-1887 | ||
| 2. | Pud Galvin* | 3355 | 1875-1892 | ||
| 3. | Cy Young* | 3167 | 1890-1911 | ||
| 4. | Gus Weyhing | 2788 | 1887-1901 | ||
| 5. | Mickey Welch* | 2556 | 1880-1892 | ||
| 6. | Tony Mullane | 2523 | 1881-1894 | ||
| 7. | Kid Nichols* | 2477 | 1890-1906 | ||
| 8. | Tim Keefe* | 2468 | 1880-1893 | ||
| 9. | John Clarkson* | 2376 | 1882-1894 | ||
| 10. | Phil Niekro* | 2337 | 1964-1987 | ||
| 11. | Adonis Terry | 2298 | 1884-1897 | ||
| 12. | Charley Radbourn* | 2275 | 1881-1891 | ||
| 13. | Nolan Ryan* | 2178 | 1966-1993 | ||
| 14. | Steve Carlton* | 2130 | 1965-1988 | ||
| 15. | Gaylord Perry* | 2128 | 1962-1983 | ||
| 16. | Red Ruffing* | 2117 | 1924-1947 | ||
| 17. | Don Sutton* | 2104 | 1966-1988 | ||
| 18. | Jim McCormick | 2095 | 1878-1887 | ||
| 19. | Amos Rusie* | 2066 | 1889-1901 | ||
| 20. | Ted Lyons* | 2056 | 1923-1946 | ||
| 21. | Burleigh Grimes* | 2048 | 1916-1934 | ||
| 22. | Jim Kaat | 2038 | 1959-1983 | ||
| 23. | Early Wynn* | 2037 | 1939-1963 | ||
| 24. | Bert Blyleven | 2029 | 1970-1992 | ||
| 25. | Jim Whitney | 2026 | 1881-1890 | ||
| 26. | Earl Whitehill | 2018 | 1923-1939 | ||
| 27. | Tommy John | 2017 | 1963-1989 | ||
| 28. | Warren Spahn* | 2016 | 1942-1965 | ||
| 29. | Sam Jones | 2007 | 1914-1935 | ||
| 30. | Chick Fraser | 1995 | 1896-1909 | ||
| 31. | Jack Powell | 1991 | 1897-1912 | ||
| 32. | Eppa Rixey* | 1986 | 1912-1933 | ||
| 33. | Greg Maddux | 1981 | 1986-2008 | ||
| 34. | Robin Roberts* | 1962 | 1948-1966 | ||
| 35. | Bert Cunningham | 1938 | 1887-1901 | ||
| 36. | Tommy Bond | 1931 | 1874-1884 | ||
| 37. | Pink Hawley | 1927 | 1892-1901 | ||
| 38. | Bill Hutchison | 1913 | 1884-1897 | ||
| 39. | Frank Tanana | 1910 | 1973-1993 | ||
| 40. | Bobo Newsom | 1908 | 1929-1953 | ||
| 41. | Walter Johnson* | 1902 | 1907-1927 | ||
| 42. | Tom Glavine | 1900 | 1987-2008 | ||
| 43. | Roger Clemens | 1885 | 1984-2007 | ||
| 44. | Jamie Moyer | 1881 | 1986-2008 | ||
| Red Ehret | 1881 | 1888-1898 | |||
| 45. | Brickyard Kennedy | 1859 | 1892-1903 | ||
| 46. | Fergie Jenkins* | 1853 | 1965-1983 | ||
| 47. | Clark Griffith* | 1852 | 1891-1914 | ||
| 48. | Pete Alexander* | 1851 | 1911-1930 | ||
| 49. | Ted Breitenstein | 1845 | 1891-1901 | ||
| 50. | Will White | 1844 | 1877-1886 | ||
| 51. | Jack Stivetts | 1836 | 1889-1899 | ||
| 52. | Dennis Martinez | 1835 | 1976-1998 | ||
| Jack Quinn | 1835 | 1909-1933 | |||
| 53. | Charlie Buffinton | 1824 | 1882-1892 | ||
| 54. | Mark Baldwin | 1817 | 1887-1893 | ||
| 55. | Jack Morris | 1815 | 1977-1994 | ||
| 56. | Red Faber* | 1813 | 1914-1933 | ||
| 57. | Silver King | 1807 | 1886-1897 | ||
| Charlie Hough | 1807 | 1970-1994 | |||
| 58. | Al Spalding* | 1791 | 1871-1877 | ||
| 59. | Frank Dwyer | 1782 | 1888-1899 | ||
| 60. | Waite Hoyt* | 1780 | 1918-1938 | ||
| 61. | Win Mercer | 1744 | 1894-1902 | ||
| 62. | Kenny Rogers | 1739 | 1989-2008 | ||
| 63. | Kid Carsey | 1722 | 1891-1901 | ||
| 64. | Guy Hecker | 1715 | 1882-1890 | ||
| 65. | Mel Harder | 1714 | 1928-1947 | ||
| 66. | George Zettlein | 1709 | 1871-1876 | ||
| 67. | Al Orth | 1704 | 1895-1909 | ||
| Jouett Meekin | 1704 | 1891-1900 | |||
| 68. | David Wells | 1702 | 1987-2007 | ||
| 69. | Jerry Reuss | 1700 | 1969-1990 | ||
| 70. | George Bradley | 1696 | 1875-1884 | ||
| 71. | Herb Pennock* | 1692 | 1912-1934 | ||
| 72. | Tom Seaver* | 1674 | 1967-1986 | ||
| 73. | Paul Derringer | 1652 | 1931-1945 | ||
| Bob Friend | 1652 | 1951-1966 | |||
| 74. | Randy Johnson | 1648 | 1988-2008 | ||
| 75. | Red Donahue | 1638 | 1893-1906 | ||
| 76. | George Mullin | 1636 | 1902-1915 | ||
| 77. | George Uhle | 1635 | 1919-1936 | ||
| 78. | Vic Willis* | 1628 | 1898-1910 | ||
| 79. | Joe Niekro | 1620 | 1967-1988 | ||
| 80. | Christy Mathewson* | 1616 | 1900-1916 | ||
| 81. | Bump Hadley | 1609 | 1926-1941 | ||
| 82. | Jerry Koosman | 1608 | 1967-1985 | ||
| 83. | Hooks Dauss | 1599 | 1912-1926 | ||
| 84. | Lefty Grove* | 1594 | 1925-1941 | ||
| 85. | Sadie McMahon | 1593 | 1889-1897 | ||
| 86. | Dick McBride | 1573 | 1871-1876 | ||
| 87. | Frank Killen | 1571 | 1891-1900 | ||
| 88. | Eddie Plank* | 1569 | 1901-1917 | ||
| 89. | Elton Chamberlain | 1560 | 1886-1896 | ||
| 90. | Mike Mussina | 1559 | 1991-2008 | ||
| 91. | Bob Feller* | 1557 | 1936-1956 | ||
| 92. | Jesse Haines* | 1556 | 1918-1937 | ||
| 93. | Charlie Getzein | 1555 | 1884-1892 | ||
| 94. | Tom Zachary | 1552 | 1918-1936 | ||
| 95. | Curt Simmons | 1551 | 1947-1967 |