| Rank | Player | Wins | Years | ||
| 1. | Walter Johnson* | 110 | 1907-1927 | ||
| 2. | Pete Alexander* | 90 | 1911-1930 | ||
| 3. | Christy Mathewson* | 79 | 1900-1916 | ||
| 4. | Cy Young* | 76 | 1890-1911 | ||
| 5. | Eddie Plank* | 69 | 1901-1917 | ||
| 6. | Warren Spahn* | 63 | 1942-1965 | ||
| 7. | Nolan Ryan* | 61 | 1966-1993 | ||
| Tom Seaver* | 61 | 1967-1986 | |||
| 8. | Bert Blyleven | 60 | 1970-1992 | ||
| 9. | Don Sutton* | 58 | 1966-1988 | ||
| 10. | Ed Walsh* | 57 | 1904-1917 | ||
| Pud Galvin* | 57 | 1875-1892 | |||
| 11. | Bob Gibson* | 56 | 1959-1975 | ||
| 12. | Mordecai Brown* | 55 | 1903-1916 | ||
| Steve Carlton* | 55 | 1965-1988 | |||
| 13. | Jim Palmer* | 53 | 1965-1984 | ||
| Gaylord Perry* | 53 | 1962-1983 | |||
| 14. | Juan Marichal* | 52 | 1960-1975 | ||
| 15. | Vic Willis* | 50 | 1898-1910 | ||
| Rube Waddell* | 50 | 1897-1910 | |||
| 16. | Luis Tiant | 49 | 1964-1982 | ||
| Early Wynn* | 49 | 1939-1963 | |||
| Don Drysdale* | 49 | 1956-1969 | |||
| Fergie Jenkins* | 49 | 1965-1983 | |||
| 17. | Kid Nichols* | 48 | 1890-1906 | ||
| 18. | Jack Powell | 46 | 1897-1912 | ||
| Roger Clemens | 46 | 1984-2007 | |||
| Tommy John | 46 | 1963-1989 | |||
| 19. | Phil Niekro* | 45 | 1964-1987 | ||
| Red Ruffing* | 45 | 1924-1947 | |||
| Robin Roberts* | 45 | 1948-1966 | |||
| Doc White | 45 | 1901-1913 | |||
| Addie Joss* | 45 | 1902-1910 | |||
| Whitey Ford* | 45 | 1950-1967 | |||
| 20. | Babe Adams | 44 | 1906-1926 | ||
| Bob Feller* | 44 | 1936-1956 | |||
| 21. | Milt Pappas | 43 | 1957-1973 | ||
| 22. | Bucky Walters | 42 | 1934-1950 | ||
| Tommy Bond | 42 | 1874-1884 | |||
| Catfish Hunter* | 42 | 1965-1979 | |||
| 23. | Mickey Lolich | 41 | 1963-1979 | ||
| Hippo Vaughn | 41 | 1908-1921 | |||
| Mickey Welch* | 41 | 1880-1892 | |||
| 24. | Claude Osteen | 40 | 1957-1975 | ||
| Sandy Koufax* | 40 | 1955-1966 | |||
| Ed Reulbach | 40 | 1905-1917 | |||
| Mel Stottlemyre | 40 | 1964-1974 | |||
| Jim Bunning* | 40 | 1955-1971 | |||
| Chief Bender* | 40 | 1903-1925 | |||
| Larry French | 40 | 1929-1942 | |||
| 25. | Tim Keefe* | 39 | 1880-1893 | ||
| Sam Leever | 39 | 1898-1910 | |||
| Jerry Reuss | 39 | 1969-1990 | |||
| 26. | Billy Pierce | 38 | 1945-1964 | ||
| Nap Rucker | 38 | 1907-1916 | |||
| Stan Coveleski* | 38 | 1912-1928 | |||
| 27. | Steve Rogers | 37 | 1973-1985 | ||
| Eppa Rixey* | 37 | 1912-1933 | |||
| John Clarkson* | 37 | 1882-1894 | |||
| Vida Blue | 37 | 1969-1986 | |||
| Randy Johnson | 37 | 1988-2008 | |||
| Larry Jackson | 37 | 1955-1968 | |||
| 28. | Camilo Pascual | 36 | 1954-1971 | ||
| Allie Reynolds | 36 | 1942-1954 | |||
| Curt Simmons | 36 | 1947-1967 | |||
| Will White | 36 | 1877-1886 | |||
| Mike Cuellar | 36 | 1959-1977 | |||
| Carl Hubbell* | 36 | 1928-1943 | |||
| Bob Friend | 36 | 1951-1966 | |||
| Sam Jones | 36 | 1914-1935 | |||
| 29. | George Mullin | 35 | 1902-1915 | ||
| Greg Maddux | 35 | 1986-2008 | |||
| Herb Pennock* | 35 | 1912-1934 | |||
| Charley Radbourn* | 35 | 1881-1891 | |||
| Jack Coombs | 35 | 1906-1920 | |||
| Joe Bush | 35 | 1912-1928 | |||
| Eddie Cicotte | 35 | 1905-1920 | |||
| Wilbur Cooper | 35 | 1912-1926 | |||
| Jack Chesbro* | 35 | 1899-1909 | |||
| Burleigh Grimes* | 35 | 1916-1934 | |||
| Bill Donovan | 35 | 1898-1918 | |||
| Lefty Grove* | 35 | 1925-1941 | |||
| 30. | Earl Moore | 34 | 1901-1914 | ||
| Frank Tanana | 34 | 1973-1993 | |||
| Jesse Tannehill | 34 | 1894-1911 | |||
| Bill Doak | 34 | 1912-1929 | |||
| 31. | Lefty Leifield | 33 | 1905-1920 | ||
| Dutch Leonard | 33 | 1913-1925 | |||
| Jim McCormick | 33 | 1878-1887 | |||
| Dave McNally | 33 | 1962-1975 | |||
| Jerry Koosman | 33 | 1967-1985 | |||
| Hal Newhouser* | 33 | 1939-1955 | |||
| Bob Shawkey | 33 | 1913-1927 | |||
| Virgil Trucks | 33 | 1941-1958 | |||
| Dean Chance | 33 | 1961-1971 | |||
| Lew Burdette | 33 | 1950-1967 | |||
| Mort Cooper | 33 | 1938-1949 | |||
| Tommy Bridges | 33 | 1930-1946 | |||
| 32. | Joe McGinnity* | 32 | 1899-1908 | ||
| Jim Perry | 32 | 1959-1975 |