| Rank | Player | Wins | Years | ||
| 1. | Nolan Ryan* | 5714 | 1966-1993 | ||
| 2. | Randy Johnson | 4789 | 1988-2008 | ||
| 3. | Roger Clemens | 4672 | 1984-2007 | ||
| 4. | Steve Carlton* | 4136 | 1965-1988 | ||
| 5. | Bert Blyleven | 3701 | 1970-1992 | ||
| 6. | Tom Seaver* | 3640 | 1967-1986 | ||
| 7. | Don Sutton* | 3574 | 1966-1988 | ||
| 8. | Gaylord Perry* | 3534 | 1962-1983 | ||
| 9. | Walter Johnson* | 3509 | 1907-1927 | ||
| 10. | Greg Maddux | 3371 | 1986-2008 | ||
| 11. | Phil Niekro* | 3342 | 1964-1987 | ||
| 12. | Fergie Jenkins* | 3192 | 1965-1983 | ||
| 13. | Pedro Martinez | 3117 | 1992-2008 | ||
| Bob Gibson* | 3117 | 1959-1975 | |||
| 14. | Curt Schilling | 3116 | 1988-2007 | ||
| 15. | John Smoltz | 3011 | 1988-2008 | ||
| 16. | Jim Bunning* | 2855 | 1955-1971 | ||
| 17. | Mickey Lolich | 2832 | 1963-1979 | ||
| 18. | Mike Mussina | 2813 | 1991-2008 | ||
| 19. | Cy Young* | 2803 | 1890-1911 | ||
| 20. | Frank Tanana | 2773 | 1973-1993 | ||
| 21. | David Cone | 2668 | 1986-2003 | ||
| 22. | Chuck Finley | 2610 | 1986-2002 | ||
| 23. | Tom Glavine | 2607 | 1987-2008 | ||
| 24. | Warren Spahn* | 2583 | 1942-1965 | ||
| 25. | Bob Feller* | 2581 | 1936-1956 | ||
| 26. | Tim Keefe* | 2562 | 1880-1893 | ||
| 27. | Jerry Koosman | 2556 | 1967-1985 | ||
| 28. | Christy Mathewson* | 2502 | 1900-1916 | ||
| 29. | Don Drysdale* | 2486 | 1956-1969 | ||
| 30. | Jack Morris | 2478 | 1977-1994 | ||
| 31. | Mark Langston | 2464 | 1984-1999 | ||
| 32. | Jim Kaat | 2461 | 1959-1983 | ||
| 33. | Sam McDowell | 2453 | 1961-1975 | ||
| 34. | Luis Tiant | 2416 | 1964-1982 | ||
| 35. | Dennis Eckersley* | 2401 | 1975-1998 | ||
| 36. | Kevin Brown | 2397 | 1986-2005 | ||
| 37. | Sandy Koufax* | 2396 | 1955-1966 | ||
| 38. | Charlie Hough | 2362 | 1970-1994 | ||
| 39. | Robin Roberts* | 2357 | 1948-1966 | ||
| 40. | Early Wynn* | 2334 | 1939-1963 | ||
| 41. | Rube Waddell* | 2316 | 1897-1910 | ||
| 42. | Juan Marichal* | 2303 | 1960-1975 | ||
| 43. | Dwight Gooden | 2293 | 1984-2000 | ||
| 44. | Lefty Grove* | 2266 | 1925-1941 | ||
| 45. | Jamie Moyer | 2248 | 1986-2008 | ||
| 46. | Eddie Plank* | 2246 | 1901-1917 | ||
| 47. | Tommy John | 2245 | 1963-1989 | ||
| 48. | Jim Palmer* | 2212 | 1965-1984 | ||
| 49. | David Wells | 2201 | 1987-2007 | ||
| 50. | Pete Alexander* | 2198 | 1911-1930 | ||
| 51. | Vida Blue | 2175 | 1969-1986 | ||
| 52. | Camilo Pascual | 2167 | 1954-1971 | ||
| 53. | Dennis Martinez | 2149 | 1976-1998 | ||
| 54. | Bobo Newsom | 2082 | 1929-1953 | ||
| 55. | Fernando Valenzuela | 2074 | 1980-1997 | ||
| 56. | Dazzy Vance* | 2045 | 1915-1935 | ||
| 57. | Rick Reuschel | 2015 | 1972-1991 | ||
| Javier Vazquez | 2015 | 1998-2008 | |||
| 58. | Orel Hershiser | 2014 | 1983-2000 | ||
| 59. | Catfish Hunter* | 2012 | 1965-1979 | ||
| 60. | Andy Pettitte | 2002 | 1995-2008 | ||
| 61. | Andy Benes | 2000 | 1989-2002 | ||
| 62. | Billy Pierce | 1999 | 1945-1964 | ||
| 63. | Kevin Appier | 1994 | 1989-2004 | ||
| 64. | Red Ruffing* | 1987 | 1924-1947 | ||
| 65. | John Clarkson* | 1978 | 1882-1894 | ||
| 66. | Al Leiter | 1974 | 1987-2005 | ||
| 67. | Bob Welch | 1969 | 1978-1994 | ||
| 68. | Kenny Rogers | 1968 | 1989-2008 | ||
| 69. | Whitey Ford* | 1956 | 1950-1967 | ||
| 70. | Bobby Witt | 1955 | 1986-2001 | ||
| 71. | Danny Darwin | 1942 | 1978-1998 | ||
| 72. | Amos Rusie* | 1934 | 1889-1901 | ||
| 73. | Tom Gordon | 1928 | 1988-2008 | ||
| 74. | Hideo Nomo | 1918 | 1995-2008 | ||
| 75. | Jerry Reuss | 1907 | 1969-1990 | ||
| Tim Wakefield | 1907 | 1992-2008 | |||
| 76. | Kid Nichols* | 1868 | 1890-1906 | ||
| 77. | Mickey Welch* | 1850 | 1880-1892 | ||
| 78. | Frank Viola | 1844 | 1982-1996 | ||
| 79. | Charley Radbourn* | 1830 | 1881-1891 | ||
| 80. | Pud Galvin* | 1806 | 1875-1892 | ||
| 81. | Tony Mullane | 1803 | 1881-1894 | ||
| 82. | Hal Newhouser* | 1796 | 1939-1955 | ||
| 83. | Ron Guidry | 1778 | 1975-1988 | ||
| 84. | John Burkett | 1766 | 1987-2003 | ||
| 85. | Rudy May | 1760 | 1965-1983 | ||
| 86. | Jason Schmidt | 1750 | 1995-2007 | ||
| 87. | Joe Niekro | 1747 | 1967-1988 | ||
| 88. | Sid Fernandez | 1743 | 1983-1997 | ||
| 89. | Dave Stewart | 1741 | 1978-1995 | ||
| 90. | Ed Walsh* | 1736 | 1904-1917 | ||
| 91. | Tom Candiotti | 1735 | 1983-1999 | ||
| 92. | Bob Friend | 1734 | 1951-1966 | ||
| 93. | Milt Pappas | 1728 | 1957-1973 | ||
| Joe Coleman | 1728 | 1965-1979 | |||
| 94. | Kevin Gross | 1727 | 1983-1997 | ||
| 95. | Floyd Bannister | 1723 | 1977-1992 | ||
| 96. | Bret Saberhagen | 1715 | 1984-2001 |