| Rank | Player | Wins | Years | ||
| 1. | Nolan Ryan* | 2795 | 1966-1993 | ||
| 2. | Steve Carlton* | 1833 | 1965-1988 | ||
| 3. | Phil Niekro* | 1809 | 1964-1987 | ||
| 4. | Early Wynn* | 1775 | 1939-1963 | ||
| 5. | Bob Feller* | 1764 | 1936-1956 | ||
| 6. | Bobo Newsom | 1732 | 1929-1953 | ||
| 7. | Amos Rusie* | 1704 | 1889-1901 | ||
| 8. | Charlie Hough | 1665 | 1970-1994 | ||
| 9. | Roger Clemens | 1580 | 1984-2007 | ||
| 10. | Gus Weyhing | 1566 | 1887-1901 | ||
| 11. | Red Ruffing* | 1541 | 1924-1947 | ||
| 12. | Tom Glavine | 1500 | 1987-2008 | ||
| 13. | Randy Johnson | 1466 | 1988-2008 | ||
| 14. | Bump Hadley | 1442 | 1926-1941 | ||
| 15. | Warren Spahn* | 1434 | 1942-1965 | ||
| 16. | Earl Whitehill | 1431 | 1923-1939 | ||
| 17. | Tony Mullane | 1408 | 1881-1894 | ||
| 18. | Sam Jones | 1396 | 1914-1935 | ||
| 19. | Jack Morris | 1390 | 1977-1994 | ||
| Tom Seaver* | 1390 | 1967-1986 | |||
| 20. | Gaylord Perry* | 1379 | 1962-1983 | ||
| 21. | Bobby Witt | 1375 | 1986-2001 | ||
| 22. | Mike Torrez | 1371 | 1967-1984 | ||
| 23. | Walter Johnson* | 1363 | 1907-1927 | ||
| 24. | Don Sutton* | 1343 | 1966-1988 | ||
| 25. | Bob Gibson* | 1336 | 1959-1975 | ||
| 26. | Chick Fraser | 1332 | 1896-1909 | ||
| Chuck Finley | 1332 | 1986-2002 | |||
| 27. | Bert Blyleven | 1322 | 1970-1992 | ||
| 28. | Sam McDowell | 1312 | 1961-1975 | ||
| 29. | Jim Palmer* | 1311 | 1965-1984 | ||
| 30. | Mark Baldwin | 1307 | 1887-1893 | ||
| 31. | Adonis Terry | 1298 | 1884-1897 | ||
| 32. | Mickey Welch* | 1297 | 1880-1892 | ||
| 33. | Burleigh Grimes* | 1295 | 1916-1934 | ||
| 34. | Mark Langston | 1289 | 1984-1999 | ||
| 35. | Kid Nichols* | 1268 | 1890-1906 | ||
| 36. | Joe Bush | 1263 | 1912-1928 | ||
| 37. | Joe Niekro | 1262 | 1967-1988 | ||
| 38. | Allie Reynolds | 1261 | 1942-1954 | ||
| 39. | Tommy John | 1259 | 1963-1989 | ||
| 40. | Frank Tanana | 1255 | 1973-1993 | ||
| 41. | Bob Lemon* | 1251 | 1946-1958 | ||
| 42. | Hal Newhouser* | 1249 | 1939-1955 | ||
| 43. | George Mullin | 1238 | 1902-1915 | ||
| 44. | Tim Keefe* | 1220 | 1880-1893 | ||
| 45. | Cy Young* | 1217 | 1890-1911 | ||
| 46. | Red Faber* | 1213 | 1914-1933 | ||
| 47. | Vic Willis* | 1212 | 1898-1910 | ||
| 48. | Ted Breitenstein | 1203 | 1891-1901 | ||
| 49. | Brickyard Kennedy | 1201 | 1892-1903 | ||
| 50. | Jerry Koosman | 1198 | 1967-1985 | ||
| 51. | Tommy Bridges | 1192 | 1930-1946 | ||
| 52. | John Clarkson* | 1191 | 1882-1894 | ||
| 53. | Lefty Grove* | 1187 | 1925-1941 | ||
| 54. | Vida Blue | 1185 | 1969-1986 | ||
| 55. | Billy Pierce | 1178 | 1945-1964 | ||
| 56. | Kenny Rogers | 1175 | 1989-2008 | ||
| 57. | Dennis Martinez | 1165 | 1976-1998 | ||
| 58. | Al Leiter | 1163 | 1987-2005 | ||
| 59. | Mike Moore | 1156 | 1982-1995 | ||
| 60. | Jack Stivetts | 1155 | 1889-1899 | ||
| 61. | Fernando Valenzuela | 1151 | 1980-1997 | ||
| 62. | David Cone | 1137 | 1986-2003 | ||
| 63. | Johnny Vander Meer | 1132 | 1937-1951 | ||
| Bill Hutchison | 1132 | 1884-1897 | |||
| 64. | Jerry Reuss | 1127 | 1969-1990 | ||
| 65. | Ted Lyons* | 1121 | 1923-1946 | ||
| Bucky Walters | 1121 | 1934-1950 | |||
| 66. | Mel Harder | 1118 | 1928-1947 | ||
| 67. | Earl Moore | 1108 | 1901-1914 | ||
| 68. | Bob Buhl | 1105 | 1953-1967 | ||
| 69. | Luis Tiant | 1104 | 1964-1982 | ||
| 70. | Mickey Lolich | 1099 | 1963-1979 | ||
| 71. | Lefty Gomez* | 1095 | 1930-1943 | ||
| 72. | Virgil Trucks | 1088 | 1941-1958 | ||
| 73. | Whitey Ford* | 1086 | 1950-1967 | ||
| 74. | Jim Kaat | 1083 | 1959-1983 | ||
| 75. | Eppa Rixey* | 1082 | 1912-1933 | ||
| 76. | Rick Sutcliffe | 1081 | 1976-1994 | ||
| 77. | Jamie Moyer | 1074 | 1986-2008 | ||
| 78. | Eddie Plank* | 1072 | 1901-1917 | ||
| Tim Wakefield | 1072 | 1992-2008 | |||
| 79. | Camilo Pascual | 1069 | 1954-1971 | ||
| 80. | Bob Turley | 1068 | 1951-1963 | ||
| 81. | Hooks Dauss | 1067 | 1912-1926 | ||
| 82. | Elton Chamberlain | 1065 | 1886-1896 | ||
| 83. | Bert Cunningham | 1064 | 1887-1901 | ||
| 84. | Curt Simmons | 1063 | 1947-1967 | ||
| 85. | Bill Donovan | 1059 | 1898-1918 | ||
| 86. | Jouett Meekin | 1058 | 1891-1900 | ||
| Murry Dickson | 1058 | 1939-1959 | |||
| 87. | Vern Kennedy | 1049 | 1934-1945 | ||
| 88. | Dizzy Trout | 1046 | 1939-1957 | ||
| 89. | Howard Ehmke | 1042 | 1915-1930 | ||
| 90. | Wes Ferrell | 1040 | 1927-1941 | ||
| 91. | Tommy Byrne | 1037 | 1943-1957 | ||
| 92. | Dave Stieb | 1034 | 1979-1998 | ||
| Dave Stewart | 1034 | 1978-1995 | |||
| Bob Welch | 1034 | 1978-1994 |