| Rank | Player | Wins | Years | ||
| 1. | Nolan Ryan* | 277 | 1966-1993 | ||
| 2. | Mickey Welch* | 274 | 1880-1892 | ||
| 3. | Tim Keefe* | 233 | 1880-1893 | ||
| 4. | Phil Niekro* | 226 | 1964-1987 | ||
| 5. | Pud Galvin* | 223 | 1875-1892 | ||
| 6. | Charley Radbourn* | 217 | 1881-1891 | ||
| 7. | Jim Whitney | 214 | 1881-1890 | ||
| 8. | Jack Morris | 206 | 1977-1994 | ||
| 9. | Tommy John | 187 | 1963-1989 | ||
| 10. | Mark Baldwin | 183 | 1887-1893 | ||
| Steve Carlton* | 183 | 1965-1988 | |||
| 11. | John Clarkson* | 182 | 1882-1894 | ||
| 12. | Charlie Hough | 179 | 1970-1994 | ||
| 13. | Joe Niekro | 172 | 1967-1988 | ||
| 14. | Kid Nichols* | 169 | 1890-1906 | ||
| 15. | Will White | 168 | 1877-1886 | ||
| 16. | Tony Mullane | 165 | 1881-1894 | ||
| 17. | John Healy | 161 | 1885-1892 | ||
| 18. | Gaylord Perry* | 160 | 1962-1983 | ||
| 19. | Jim McCormick | 157 | 1878-1887 | ||
| 20. | Cy Young* | 156 | 1890-1911 | ||
| Red Ames | 156 | 1903-1919 | |||
| 21. | Walter Johnson* | 155 | 1907-1927 | ||
| 22. | Charlie Buffinton | 154 | 1882-1892 | ||
| 23. | Amos Rusie* | 153 | 1889-1901 | ||
| 24. | David Cone | 149 | 1986-2003 | ||
| 25. | Adonis Terry | 148 | 1884-1897 | ||
| 26. | John Smoltz | 145 | 1988-2008 | ||
| Ed Crane | 145 | 1884-1893 | |||
| 27. | John Ward* | 144 | 1878-1884 | ||
| 28. | Roger Clemens | 143 | 1984-2007 | ||
| 29. | Sam McDowell | 140 | 1961-1975 | ||
| 30. | George Bradley | 139 | 1875-1884 | ||
| 31. | Mike Moore | 135 | 1982-1995 | ||
| Chick Fraser | 135 | 1896-1909 | |||
| 32. | Gus Weyhing | 130 | 1887-1901 | ||
| Chuck Finley | 130 | 1986-2002 | |||
| 33. | Jim Kaat | 128 | 1959-1983 | ||
| Bobby Witt | 128 | 1986-2001 | |||
| 34. | Tom Seaver* | 126 | 1967-1986 | ||
| 35. | Mickey Lolich | 124 | 1963-1979 | ||
| Jim Maloney | 124 | 1960-1971 | |||
| 36. | Jack Stivetts | 122 | 1889-1899 | ||
| Bill Hutchison | 122 | 1884-1897 | |||
| 37. | Orel Hershiser | 121 | 1983-2000 | ||
| 38. | Tom Candiotti | 120 | 1983-1999 | ||
| 39. | Fernando Valenzuela | 119 | 1980-1997 | ||
| Frank Tanana | 119 | 1973-1993 | |||
| Larry Cheney | 119 | 1911-1919 | |||
| Tony Cloninger | 119 | 1961-1972 | |||
| 40. | Dave Stewart | 118 | 1978-1995 | ||
| Joe Coleman | 118 | 1965-1979 | |||
| 41. | Jouett Meekin | 114 | 1891-1900 | ||
| Christy Mathewson* | 114 | 1900-1916 | |||
| Bert Blyleven | 114 | 1970-1992 | |||
| 42. | Larry Corcoran | 113 | 1880-1887 | ||
| John Harkins | 113 | 1884-1888 | |||
| 43. | Lindy McDaniel | 112 | 1955-1975 | ||
| Don Sutton* | 112 | 1966-1988 | |||
| 44. | Charlie Getzein | 111 | 1884-1892 | ||
| 45. | Tom Gordon | 110 | 1988-2008 | ||
| 46. | Hideo Nomo | 109 | 1995-2008 | ||
| 47. | Kevin Brown | 108 | 1986-2005 | ||
| Bob Gibson* | 108 | 1959-1975 | |||
| 48. | Jerry Reuss | 107 | 1969-1990 | ||
| Mark Gubicza | 107 | 1984-1997 | |||
| 49. | Kevin Appier | 106 | 1989-2004 | ||
| 50. | Mike Morgan | 105 | 1978-2002 | ||
| Silver King | 105 | 1886-1897 | |||
| Juan Guzman | 105 | 1991-2000 | |||
| 51. | Matt Kilroy | 104 | 1886-1898 | ||
| Tim Wakefield | 104 | 1992-2008 | |||
| Larry Dierker | 104 | 1964-1977 | |||
| Randy Johnson | 104 | 1988-2008 | |||
| 52. | Mike Torrez | 103 | 1967-1984 | ||
| Vida Blue | 103 | 1969-1986 | |||
| 53. | David Wells | 101 | 1987-2007 | ||
| Jim Clancy | 101 | 1977-1991 | |||
| Matt Clement | 101 | 1998-2006 | |||
| Henry Gruber | 101 | 1887-1891 | |||
| George Haddock | 101 | 1888-1894 | |||
| 54. | Rick Sutcliffe | 100 | 1976-1994 | ||
| 55. | Bert Cunningham | 99 | 1887-1901 | ||
| 56. | Ken Holtzman | 98 | 1965-1979 | ||
| 57. | Dutch Leonard | 97 | 1933-1953 | ||
| Johnny Klippstein | 97 | 1950-1967 | |||
| Darryl Kile | 97 | 1991-2002 | |||
| Milt Pappas | 97 | 1957-1973 | |||
| Eppa Rixey* | 97 | 1912-1933 | |||
| Jim Slaton | 97 | 1971-1986 | |||
| Ron Darling | 97 | 1983-1995 | |||
| 58. | Jason Grimsley | 96 | 1989-2006 | ||
| Hank Gastright | 96 | 1889-1896 | |||
| 59. | Vic Willis* | 95 | 1898-1910 | ||
| Stump Wiedman | 95 | 1880-1888 | |||
| Elton Chamberlain | 95 | 1886-1896 | |||
| Ed Daily | 95 | 1885-1891 | |||
| 60. | Bobby Mathews | 94 | 1871-1887 | ||
| Ray Sadecki | 94 | 1960-1977 | |||
| Harry Staley | 94 | 1888-1895 |