| Rank | Player | Wins | Years | ||
| 1. | Cy Young* | 511 | 1890-1911 | ||
| 2. | Walter Johnson* | 417 | 1907-1927 | ||
| 3. | Christy Mathewson* | 373 | 1900-1916 | ||
| Pete Alexander* | 373 | 1911-1930 | |||
| 4. | Pud Galvin* | 364 | 1875-1892 | ||
| 5. | Warren Spahn* | 363 | 1942-1965 | ||
| 6. | Kid Nichols* | 361 | 1890-1906 | ||
| 7. | Greg Maddux | 355 | 1986-2008 | ||
| 8. | Roger Clemens | 354 | 1984-2007 | ||
| 9. | Tim Keefe* | 342 | 1880-1893 | ||
| 10. | Steve Carlton* | 329 | 1965-1988 | ||
| 11. | John Clarkson* | 328 | 1882-1894 | ||
| 12. | Eddie Plank* | 326 | 1901-1917 | ||
| 13. | Don Sutton* | 324 | 1966-1988 | ||
| Nolan Ryan* | 324 | 1966-1993 | |||
| 14. | Phil Niekro* | 318 | 1964-1987 | ||
| 15. | Gaylord Perry* | 314 | 1962-1983 | ||
| 16. | Tom Seaver* | 311 | 1967-1986 | ||
| 17. | Charley Radbourn* | 309 | 1881-1891 | ||
| 18. | Mickey Welch* | 307 | 1880-1892 | ||
| 19. | Tom Glavine | 305 | 1987-2008 | ||
| 20. | Early Wynn* | 300 | 1939-1963 | ||
| Lefty Grove* | 300 | 1925-1941 | |||
| 21. | Bobby Mathews | 297 | 1871-1887 | ||
| 22. | Randy Johnson | 295 | 1988-2008 | ||
| 23. | Tommy John | 288 | 1963-1989 | ||
| 24. | Bert Blyleven | 287 | 1970-1992 | ||
| 25. | Robin Roberts* | 286 | 1948-1966 | ||
| 26. | Tony Mullane | 284 | 1881-1894 | ||
| Fergie Jenkins* | 284 | 1965-1983 | |||
| 27. | Jim Kaat | 283 | 1959-1983 | ||
| 28. | Red Ruffing* | 273 | 1924-1947 | ||
| 29. | Mike Mussina | 270 | 1991-2008 | ||
| Burleigh Grimes* | 270 | 1916-1934 | |||
| 30. | Jim Palmer* | 268 | 1965-1984 | ||
| 31. | Eppa Rixey* | 266 | 1912-1933 | ||
| Bob Feller* | 266 | 1936-1956 | |||
| 32. | Jim McCormick | 265 | 1878-1887 | ||
| 33. | Gus Weyhing | 264 | 1887-1901 | ||
| 34. | Ted Lyons* | 260 | 1923-1946 | ||
| 35. | Jack Morris | 254 | 1977-1994 | ||
| Red Faber* | 254 | 1914-1933 | |||
| 36. | Al Spalding* | 253 | 1871-1877 | ||
| Carl Hubbell* | 253 | 1928-1943 | |||
| 37. | Bob Gibson* | 251 | 1959-1975 | ||
| 38. | Vic Willis* | 249 | 1898-1910 | ||
| 39. | Jack Quinn | 247 | 1909-1933 | ||
| 40. | Joe McGinnity* | 246 | 1899-1908 | ||
| Jamie Moyer | 246 | 1986-2008 | |||
| 41. | Dennis Martinez | 245 | 1976-1998 | ||
| Jack Powell | 245 | 1897-1912 | |||
| Amos Rusie* | 245 | 1889-1901 | |||
| 42. | Juan Marichal* | 243 | 1960-1975 | ||
| 43. | Herb Pennock* | 240 | 1912-1934 | ||
| Frank Tanana | 240 | 1973-1993 | |||
| 44. | David Wells | 239 | 1987-2007 | ||
| Mordecai Brown* | 239 | 1903-1916 | |||
| 45. | Clark Griffith* | 237 | 1891-1914 | ||
| Waite Hoyt* | 237 | 1918-1938 | |||
| 46. | Whitey Ford* | 236 | 1950-1967 | ||
| 47. | Tommy Bond | 234 | 1874-1884 | ||
| 48. | Charlie Buffinton | 233 | 1882-1892 | ||
| 49. | Luis Tiant | 229 | 1964-1982 | ||
| Will White | 229 | 1877-1886 | |||
| Sam Jones | 229 | 1914-1935 | |||
| 50. | George Mullin | 228 | 1902-1915 | ||
| 51. | Jim Bunning* | 224 | 1955-1971 | ||
| Catfish Hunter* | 224 | 1965-1979 | |||
| 52. | Paul Derringer | 223 | 1931-1945 | ||
| Mel Harder | 223 | 1928-1947 | |||
| 53. | Jerry Koosman | 222 | 1967-1985 | ||
| Hooks Dauss | 222 | 1912-1926 | |||
| 54. | Joe Niekro | 221 | 1967-1988 | ||
| 55. | Jerry Reuss | 220 | 1969-1990 | ||
| 56. | Kenny Rogers | 219 | 1989-2008 | ||
| 57. | Earl Whitehill | 218 | 1923-1939 | ||
| Bob Caruthers | 218 | 1884-1892 | |||
| 58. | Mickey Lolich | 217 | 1963-1979 | ||
| Freddie Fitzsimmons | 217 | 1925-1943 | |||
| 59. | Curt Schilling | 216 | 1988-2007 | ||
| Wilbur Cooper | 216 | 1912-1926 | |||
| Charlie Hough | 216 | 1970-1994 | |||
| 60. | Jim Perry | 215 | 1959-1975 | ||
| Andy Pettitte | 215 | 1995-2008 | |||
| Stan Coveleski* | 215 | 1912-1928 | |||
| 61. | Pedro Martinez | 214 | 1992-2008 | ||
| Rick Reuschel | 214 | 1972-1991 | |||
| 62. | Chief Bender* | 212 | 1903-1925 | ||
| 63. | Bobo Newsom | 211 | 1929-1953 | ||
| Billy Pierce | 211 | 1945-1964 | |||
| Bob Welch | 211 | 1978-1994 | |||
| Kevin Brown | 211 | 1986-2005 | |||
| 64. | John Smoltz | 210 | 1988-2008 | ||
| Jesse Haines* | 210 | 1918-1937 | |||
| 65. | Milt Pappas | 209 | 1957-1973 | ||
| Vida Blue | 209 | 1969-1986 | |||
| Don Drysdale* | 209 | 1956-1969 | |||
| 66. | Eddie Cicotte | 208 | 1905-1920 | ||
| 67. | Bob Lemon* | 207 | 1946-1958 | ||
| Carl Mays | 207 | 1915-1929 |