| Rank | Player | Losses | Year | Age | ||
| 1. | John Coleman | 48 | 1883 | 20 | ||
| 2. | Will White | 42 | 1880 | 25 | ||
| 3. | Larry McKeon | 41 | 1884 | 18 | ||
| 4. | George Bradley | 40 | 1879 | 26 | ||
| Jim McCormick | 40 | 1879 | 22 | |||
| 5. | George Cobb | 37 | 1892 | 26 | ||
| Kid Carsey | 37 | 1891 | 20 | |||
| Henry Porter | 37 | 1888 | 29 | |||
| 6. | Bill Hutchison | 36 | 1892 | 32 | ||
| Stump Wiedman | 36 | 1886 | 25 | |||
| 7. | Red Donahue | 35 | 1897 | 24 | ||
| Hardie Henderson | 35 | 1885 | 22 | |||
| Fleury Sullivan | 35 | 1884 | 22 | |||
| Adonis Terry | 35 | 1884 | 19 | |||
| Pud Galvin* | 35 | 1880 | 23 | |||
| Jim Devlin | 35 | 1876 | 26 | |||
| 8. | Amos Rusie* | 34 | 1890 | 19 | ||
| Mark Baldwin | 34 | 1889 | 25 | |||
| Al Mays | 34 | 1887 | 22 | |||
| Matt Kilroy | 34 | 1886 | 19 | |||
| Bob Barr | 34 | 1884 | 27 | |||
| Bobby Mathews | 34 | 1876 | 24 | |||
| 9. | Jersey Bakely | 33 | 1888 | 24 | ||
| Dupee Shaw | 33 | 1884 | 25 | |||
| Hardie Henderson | 33 | 1883 | 20 | |||
| Frank Mountain | 33 | 1883 | 23 | |||
| Lee Richmond | 33 | 1882 | 25 | |||
| Jim Whitney | 33 | 1881 | 23 | |||
| Harry McCormick | 33 | 1879 | 23 | |||
| 10. | Jim Whitney | 32 | 1886 | 28 | ||
| Jim Whitney | 32 | 1885 | 27 | |||
| John Harkins | 32 | 1884 | 25 | |||
| Lee Richmond | 32 | 1880 | 23 | |||
| 11. | Amos Rusie* | 31 | 1892 | 21 | ||
| Billy Crowell | 31 | 1887 | 21 | |||
| Charley Radbourn* | 31 | 1886 | 31 | |||
| Dupee Shaw | 31 | 1886 | 27 | |||
| Will White | 31 | 1879 | 24 | |||
| Sam Weaver | 31 | 1878 | 22 | |||
| 12. | Jim Hughey | 30 | 1899 | 30 | ||
| Ted Breitenstein | 30 | 1895 | 25 | |||
| Ed Beatin | 30 | 1890 | 23 | |||
| John Ewing | 30 | 1889 | 25 | |||
| Toad Ramsey | 30 | 1888 | 23 | |||
| Phenomenal Smith | 30 | 1887 | 22 | |||
| Jack Lynch | 30 | 1886 | 29 | |||
| Jersey Bakely | 30 | 1884 | 20 | |||
| Jim McCormick | 30 | 1882 | 25 | |||
| Jim McCormick | 30 | 1881 | 24 | |||
| Mickey Welch* | 30 | 1880 | 20 | |||
| 13. | Vic Willis* | 29 | 1905 | 29 | ||
| Jack Taylor | 29 | 1898 | 25 | |||
| Bill Hart | 29 | 1896 | 30 | |||
| Silver King | 29 | 1891 | 23 | |||
| Red Ehret | 29 | 1889 | 20 | |||
| Bert Cunningham | 29 | 1888 | 22 | |||
| Hank O'Day | 29 | 1888 | 25 | |||
| John Healy | 29 | 1887 | 20 | |||
| Pud Galvin* | 29 | 1883 | 26 | |||
| Tommy Bond | 29 | 1880 | 24 | |||
| 14. | Bill Hill | 28 | 1896 | 21 | ||
| Duke Esper | 28 | 1893 | 24 | |||
| Mark Baldwin | 28 | 1891 | 27 | |||
| Gus Weyhing | 28 | 1887 | 20 | |||
| Al Mays | 28 | 1886 | 21 | |||
| Hugh Daily | 28 | 1884 | 27 | |||
| Hank O'Day | 28 | 1884 | 21 | |||
| Doc Landis | 28 | 1882 | 27 | |||
| Jim McCormick | 28 | 1880 | 23 | |||
| 15. | Paul Derringer | 27 | 1933 | 26 | ||
| George Bell | 27 | 1910 | 35 | |||
| Dummy Taylor | 27 | 1901 | 26 | |||
| Bill Carrick | 27 | 1899 | 25 | |||
| Willie Sudhoff | 27 | 1898 | 23 | |||
| Bill Hart | 27 | 1897 | 31 | |||
| Chick Fraser | 27 | 1896 | 22 | |||
| Pink Hawley | 27 | 1894 | 21 | |||
| Mark Baldwin | 27 | 1892 | 28 | |||
| Phil Knell | 27 | 1891 | 26 | |||
| Park Swartzel | 27 | 1889 | 23 | |||
| Toad Ramsey | 27 | 1887 | 22 | |||
| Toad Ramsey | 27 | 1886 | 21 | |||
| Tony Mullane | 27 | 1886 | 27 | |||
| Charlie Buffinton | 27 | 1885 | 23 | |||
| Tim Keefe* | 27 | 1883 | 26 | |||
| Tim Keefe* | 27 | 1881 | 24 | |||
| Pud Galvin* | 27 | 1879 | 22 | |||
| 16. | Bob Groom | 26 | 1909 | 24 | ||
| Gus Dorner | 26 | 1906 | 29 | |||
| Happy Townsend | 26 | 1904 | 25 | |||
| Pete Dowling | 26 | 1901 | ||||
| Gus Weyhing | 26 | 1898 | 31 | |||
| Ted Breitenstein | 26 | 1896 | 26 | |||
| Frank Killen | 26 | 1892 | 21 | |||
| Tony Mullane | 26 | 1891 | 32 | |||
| George Haddock | 26 | 1890 | 23 | |||
| Harry Staley | 26 | 1889 | 22 | |||
| John Kirby | 26 | 1886 | 21 | |||
| Pud Galvin* | 26 | 1885 | 28 | |||
| Dupee Shaw | 26 | 1885 | 26 |