| Rank | Player | Runs | Year | Age | ||
| 1. | John Coleman | 510 | 1883 | 20 | ||
| 2. | Will White | 404 | 1879 | 24 | ||
| 3. | Bobby Mathews | 395 | 1876 | 24 | ||
| 4. | Phenomenal Smith | 369 | 1887 | 22 | ||
| 5. | Pud Galvin* | 367 | 1883 | 26 | ||
| 6. | George Bradley | 361 | 1879 | 26 | ||
| 7. | Al Mays | 359 | 1887 | 22 | ||
| 8. | Kid Carsey | 358 | 1891 | 20 | ||
| Mark Baldwin | 358 | 1889 | 25 | |||
| Toad Ramsey | 358 | 1887 | 22 | |||
| 9. | Henry Gruber | 352 | 1890 | 26 | ||
| 10. | Billy Crowell | 350 | 1887 | 21 | ||
| Matt Kilroy | 350 | 1886 | 19 | |||
| Larry McKeon | 350 | 1884 | 18 | |||
| 11. | Frank Mountain | 345 | 1883 | 23 | ||
| 12. | Lee Richmond | 343 | 1882 | 25 | ||
| 13. | Gus Weyhing | 342 | 1887 | 20 | ||
| 14. | Mike Morrison | 341 | 1887 | 20 | ||
| 15. | Hardie Henderson | 339 | 1883 | 20 | ||
| 16. | Jersey Bakely | 338 | 1884 | 20 | ||
| 17. | Henry Porter | 336 | 1888 | 29 | ||
| 18. | Park Swartzel | 334 | 1889 | 23 | ||
| 19. | George Cobb | 333 | 1892 | 26 | ||
| 20. | Fleury Sullivan | 328 | 1884 | 22 | ||
| 21. | Bob Barr | 327 | 1884 | 27 | ||
| 22. | Matt Kilroy | 326 | 1887 | 20 | ||
| 23. | Stump Wiedman | 323 | 1886 | 25 | ||
| Will White | 323 | 1880 | 25 | |||
| 24. | Mark Baldwin | 322 | 1890 | 26 | ||
| 25. | Ted Breitenstein | 321 | 1894 | 24 | ||
| Jersey Bakely | 321 | 1888 | 24 | |||
| Mickey Welch* | 321 | 1880 | 20 | |||
| 26. | Bill Hutchison | 316 | 1892 | 32 | ||
| 27. | Bill Hutchison | 315 | 1890 | 30 | ||
| Tony Mullane | 315 | 1886 | 27 | |||
| 28. | Hardie Henderson | 311 | 1885 | 22 | ||
| 29. | Jim Devlin | 309 | 1876 | 26 | ||
| 30. | Kid Nichols* | 308 | 1894 | 24 | ||
| Adonis Terry | 308 | 1884 | 19 | |||
| Jim McCormick | 308 | 1879 | 22 | |||
| 31. | Jersey Bakely | 307 | 1890 | 26 | ||
| George Haddock | 307 | 1890 | 23 | |||
| Jack Lynch | 307 | 1886 | 29 | |||
| 32. | Red Donahue | 306 | 1897 | 24 | ||
| Pink Hawley | 306 | 1894 | 21 | |||
| 33. | Charley Radbourn* | 305 | 1887 | 32 | ||
| 34. | Lee Richmond | 302 | 1881 | 24 | ||
| 35. | Ed Beatin | 300 | 1890 | 23 | ||
| Amos Rusie* | 300 | 1890 | 19 | |||
| Charley Radbourn* | 300 | 1886 | 31 | |||
| John Harkins | 300 | 1884 | 25 | |||
| 36. | Pud Galvin* | 299 | 1879 | 22 | ||
| 37. | Tommy Bond | 298 | 1880 | 24 | ||
| 38. | Toad Ramsey | 297 | 1886 | 21 | ||
| Charlie Ferguson | 297 | 1884 | 21 | |||
| 39. | John Ewing | 296 | 1889 | 25 | ||
| 40. | Ted Breitenstein | 295 | 1895 | 25 | ||
| 41. | Bill Sweeney | 294 | 1884 | |||
| 42. | Bert Cunningham | 293 | 1890 | 24 | ||
| Ed Seward | 293 | 1887 | 19 | |||
| 43. | Bill Hart | 292 | 1897 | 31 | ||
| John Healy | 292 | 1887 | 20 | |||
| Jim Whitney | 292 | 1886 | 28 | |||
| 44. | Brickyard Kennedy | 291 | 1894 | 26 | ||
| Harry McCormick | 291 | 1879 | 23 | |||
| 45. | Amos Rusie* | 288 | 1892 | 21 | ||
| Al Atkinson | 288 | 1886 | 25 | |||
| Terry Larkin | 288 | 1878 | ||||
| Jim Devlin | 288 | 1877 | 27 | |||
| Lon Knight | 288 | 1876 | 22 | |||
| 46. | Sadie McMahon | 287 | 1890 | 22 | ||
| Red Ehret | 287 | 1889 | 20 | |||
| Guy Hecker | 287 | 1883 | 27 | |||
| 47. | Frank Killen | 286 | 1892 | 21 | ||
| Jim Whitney | 286 | 1885 | 27 | |||
| Larry Corcoran | 286 | 1884 | 24 | |||
| 48. | Billy Serad | 285 | 1884 | 21 | ||
| Terry Larkin | 285 | 1877 | ||||
| 49. | Jim Whitney | 284 | 1881 | 23 | ||
| 50. | Bill Hutchison | 283 | 1891 | 31 | ||
| Matt Kilroy | 283 | 1889 | 22 | |||
| John Clarkson* | 283 | 1887 | 25 | |||
| 51. | Chick Fraser | 282 | 1896 | 22 | ||
| Jack Taylor | 282 | 1896 | 23 | |||
| Frank Dwyer | 282 | 1894 | 26 | |||
| 52. | Dupee Shaw | 281 | 1884 | 25 | ||
| Larry Corcoran | 281 | 1883 | 23 | |||
| Pud Galvin* | 281 | 1880 | 23 | |||
| 53. | Win Mercer | 280 | 1895 | 20 | ||
| Ed Crane | 280 | 1890 | 28 | |||
| John Clarkson* | 280 | 1889 | 27 | |||
| 54. | Mickey Welch* | 279 | 1886 | 26 | ||
| 55. | Win Mercer | 278 | 1894 | 19 | ||
| Jack Stivetts | 278 | 1894 | 26 | |||
| Mark Baldwin | 278 | 1891 | 27 | |||
| Toad Ramsey | 278 | 1888 | 23 | |||
| Lee Richmond | 278 | 1880 | 23 | |||
| 56. | Duke Esper | 277 | 1893 | 24 | ||
| Henry Porter | 277 | 1886 | 27 | |||
| Terry Larkin | 277 | 1879 |