I
Bold indicates Hall of Famer.
*Indicates active as of 2008.
| Chris Iannetta* | 2006-2008 |
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| Raul Ibanez* | 1996-2008 |
| Ham Iburg | 1902-1902 |
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| Kei Igawa* | 2007-2008 |
| Gary Ignasiak | 1973-1973 |
| Mike Ignasiak | 1991-1995 |
| Tadahito Iguchi* | 2005-2008 |
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| Blaise Ilsley | 1994-1994 |
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| Doc Imlay | 1913-1913 |
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| Pete Incaviglia | 1986-1998 |
| Alexis Infante | 1987-1990 |
| Omar Infante* | 2002-2008 |
| Brandon Inge* | 2001-2008 |
| Bob Ingersoll | 1914-1914 |
| Scotty Ingerton | 1911-1911 |
| Joe Inglett* | 2006-2008 |
| Charlie Ingraham | 1883-1883 |
| Garey Ingram | 1994-1997 |
| Mel Ingram | 1929-1929 |
| Riccardo Ingram | 1994-1995 |
| Bert Inks | 1891-1896 |
| Jeff Innis | 1987-1993 |
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| Dane Iorg | 1977-1986 |
| Garth Iorg | 1978-1987 |
| Happy Iott | 1903-1903 |
| Hooks Iott | 1941-1947 |
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| Hideki Irabu | 1997-2002 |
| Hal Irelan | 1914-1914 |
| Tim Ireland | 1981-1982 |
| Hernan Iribarren* | 2008-2008 |
| Daryl Irvine | 1990-1992 |
| Ed Irvin | 1912-1912 |
| Monte Irvin | 1949-1956 |
| Arthur Irwin | 1880-1894 |
| Bill Irwin | 1886-1886 |
| Charlie Irwin | 1893-1902 |
| John Irwin | 1882-1891 |
| Tommy Irwin | 1938-1938 |
| Walt Irwin | 1921-1921 |
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| Orlando Isales | 1980-1980 |
| Frank Isbell | 1898-1909 |
| Kazuhisa Ishii | 2002-2005 |
| Travis Ishikawa* | 2006-2008 |
| Jason Isringhausen* | 1995-2008 |
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| Mike Ivie | 1971-1983 |
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| Akinori Iwamura* | 2007-2008 |
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| Hank Izquierdo | 1967-1967 |
| Hansel Izquierdo | 2002-2002 |
| Cesar Izturis* | 2001-2008 |
| Maicer Izturis* | 2004-2008 |
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